Journal ArticleDOI
Indole alkaloids from the roots of Isatis ingigotica and their antiherpes simplex virus type 2 (HSV-2) activity in vitro
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TLDR
A new indole alkaloid, together with four known indole alkaloids, was isolated from the 95% EtOH extract of the traditional Chinese medicinal plant Isatis indigotica as mentioned in this paper.Abstract:
A new indole alkaloid 1, together with four known indole alkaloids 2–5, was isolated from the 95% EtOH extract of the traditional Chinese medicinal plant Isatis indigotica. Alkaloids 2–5 were found in the plant for the first time. Their structures were elucidated as 3-hydroxy-3-acetonitrile-4-hydroxy-2-indolone (1), 1-methoxy-3-indoleacetonitrile (2), 3-indoleacetic acid (3), 3-indolealdehyde (4), and 1-methoxy-3indolecarbaldehyde (5) on the basis of spectroscopic data. Their anti-HSV effects in vitro were evaluated by plaque reduction assay.read more
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Alkaloids from the Root of Isatis indigotica
Minghua Chen,Li-She Gan,Sheng Lin,Xiaoliang Wang,Li Li,Yu-Huan Li,Cheng-Gen Zhu,Yanan Wang,Bingya Jiang,Jian-Dong Jiang,Yongchun Yang,Jiangong Shi +11 more
TL;DR: Seventeen new alkaloids and 14 known analogues have been isolated from an aqueous extract of the root of Isatis indigotica by extensive spectroscopic data analysis, including 2D NMR, single-crystal X-ray crystallography using anomalous scattering of Cu Kα radiation, and electronic circular dichroism spectra calculations based on the quantum-mechanical time-dependent density functional theory.
Journal ArticleDOI
Enantiomers of an Indole Alkaloid Containing Unusual Dihydrothiopyran and 1,2,4-Thiadiazole Rings from the Root of Isatis indigotica
Minghua Chen,Sheng Lin,Li Li,Cheng-Gen Zhu,Xiaoliang Wang,Yanan Wang,Bingya Jiang,Sujuan Wang,Yu-Huan Li,Jian-Dong Jiang,Jiangong Shi +10 more
TL;DR: A pair of enantiomers of an indole alkaloid containing dihydrothiopyran and 1,2,4-thiadiazole rings was isolated from an aqueous extract of the root of Isatis indigotica by extensive spectroscopic analysis.
Journal ArticleDOI
Research progress of Chinese herbal medicine Radix isatidis (banlangen).
Wei Zhou,Xiao-Yan Zhang +1 more
TL;DR: Wang et al. as mentioned in this paper inferred that the antiviral activity of R. isatidis mostly depended on the water-soluble part, including amino acids, IRPS, nucleosides, and sulfur-containing alkaloids.
Journal ArticleDOI
A chromosome-scale genome assembly of Isatis indigotica , an important medicinal plant used in traditional Chinese medicine: An Isatis genome.
Minghui Kang,Haolin Wu,Qiao Yang,Li Huang,Quanjun Hu,Tao Ma,Zaiyun Li,Jianquan Liu,Jianquan Liu +8 more
TL;DR: A high-quality chromosome-scale genome assembly of I. indigotica is reported and many candidate genes involved in the biosynthesis of main active components such as indoles, terpenoids, and phenylpropanoids are identified, highlighting the importance of genome sequencing in identifying candidate genes for metabolite synthesis in medicinal plants.
Journal ArticleDOI
An unusual indole alkaloid with anti-adenovirus and anti-HSV activities from Alstonia scholaris
TL;DR: The 17-nor-excelsinidine (1) and strictamine (2) showed significant inhibitory activity against herpes simplex virus (HSV) and adenovirus (ADV).
References
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Journal Article
Evaluation of a Soluble Tetrazolium/Formazan Assay for Cell Growth and Drug Sensitivity in Culture Using Human and Other Tumor Cell Lines
Dominic A. Scudiero,Robert H. Shoemaker,Kenneth D. Paull,Anne Monks,Siobhan Tierney,Thomas H. Nofziger,Michael J. Currens,Donna Seniff,Michael R. Boyd +8 more
TL;DR: The new XTT reagent provides for a simplified, in vitro cell growth assay with possible applicability to a variety of problems in cellular pharmacology and biology, but still shares many of the limitations and potential pitfalls of MTT or other tetrazolium-based assays.
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Antiherpes simplex virus type 2 activity of casuarinin from the bark of Terminalia arjuna Linn.
TL;DR: It is concluded that casuarinin possesses anti-herpesvirus activity in inhibiting viral attachment and penetration, and also disturbing the late event(s) of infection.
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The effect of medicinal plants used in Chinese folk medicine on RANTES secretion by virus-infected human epithelial cells.
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Phytoalexins from Thlaspi arvense, a wild crucifer resistant to virulent Leptosphaeria maculans: structures, syntheses and antifungal activity.
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Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in vitro
TL;DR: The acetone, ethanol and methanol extracts of P. urinaria were concluded to likely inhibit HSV-2 infection through disturbing the early stage of virus infection and through diminishing the virus infectivity.