H
Hanna Taipaleenmaki
Researcher at University of Hamburg
Publications - 16
Citations - 1252
Hanna Taipaleenmaki is an academic researcher from University of Hamburg. The author has contributed to research in topics: Wnt signaling pathway & Metastasis. The author has an hindex of 13, co-authored 16 publications receiving 1090 citations. Previous affiliations of Hanna Taipaleenmaki include University of Massachusetts Medical School.
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Journal ArticleDOI
miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells
Mohammad Q. Hassan,Yukiko Maeda,Hanna Taipaleenmaki,Weibing Zhang,Mohammad Jafferji,Jonathan A. R. Gordon,Zhaoyong Li,Carlo M. Croce,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +11 more
TL;DR: In this paper, the authors show that miR-218 is induced during osteoblast differentiation and has potent osteogenic properties, which can promote commitment and differentiation of bone marrow stromal cells by activating a positive Wnt signaling loop.
miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of
Mohammad Q. Hassan,Yukiko Maeda,Hanna Taipaleenmaki,Weibing Zhang,Mohammad Jafferji,Jonathan A. R. Gordon,Zhaoyong Li,Carlo M. Croce,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +11 more
TL;DR: In metastatic breast cancer cells but not in normal mammary epithelial cells, miR-218 enhances Wnt activity and abnormal expression of osteoblastic genes (osteomimicry) that contribute to homing and growth of cells metastatic to bone.
Journal ArticleDOI
Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease
Hanna Taipaleenmaki,Hanna Taipaleenmaki,Gillian Browne,Jacqueline Akech,Jozef Zustin,Andre J. van Wijnen,Janet L. Stein,Eric Hesse,Gary S. Stein,Jane B. Lian,Jane B. Lian +10 more
TL;DR: It is identified that aberrant expression of Runx2 in aggressive tumor cells is related to the loss of specific Runx 2-targeting miRNAs and that a clinically relevant replacement strategy by delivery of synthetic miRNas is a candidate for a therapeutic approach to prevent metastatic bone disease by this route.
Journal ArticleDOI
Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost is Mediated by Estrogen Receptor β
Gabriel L. Galea,Lee B Meakin,Toshihiro Sugiyama,Noureddine Zebda,Andrew Sunters,Hanna Taipaleenmaki,Gary S. Stein,Andre J. Van Wijnen,Lance E. Lanyon,Joanna S. Price +9 more
TL;DR: In this paper, the differential effects of ERα and -β in these processes in mouse long bone-derived osteoblastic cells and human Saos-2 cells were investigated, and it was shown that ERβ inhibition with 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-β]pyrimidin-3-yl] phenol (PTHPP) increases basal proliferation similarly to strain or estradiol.
Journal ArticleDOI
MicroRNA-34c Inversely Couples the Biological Functions of the Runt-related Transcription Factor RUNX2 and the Tumor Suppressor p53 in Osteosarcoma
Margaretha Van der Deen,Hanna Taipaleenmaki,Hanna Taipaleenmaki,Ying Zhang,Nadiya M. Teplyuk,Anurag Gupta,Senthilkumar Cinghu,Kristen Shogren,Avudaiappan Maran,Michael J. Yaszemski,Ling Ling,Simon M. Cool,Simon M. Cool,David Tai Leong,Christian Dierkes,Jozef Zustin,Manuel Salto-Tellez,Manuel Salto-Tellez,Yoshiaki Ito,Suk-Chul Bae,Maria Zielenska,Jeremy A. Squire,Jane B. Lian,Jane B. Lian,Janet L. Stein,Janet L. Stein,Gerard P. Zambetti,Stephen N. Jones,Mario Galindo,Eric Hesse,Gary S. Stein,Gary S. Stein,Andre J. van Wijnen +32 more
TL;DR: A novel p53-miR-34c-RUNX2 network controls cell growth of osseous cells and is compromised in OS, which is a primary bone tumor that is most prevalent during adolescence.