Andre J. Van Wijnen

TL;DR: Runx2 is identified as the first transcription factor to interact with HDAC6 and it is suggested thatHDAC6 may bind to Runx2 in differentiating osteoblasts to regulate tissue-specific gene expression.

TL;DR: It is proposed that multiple HD proteins in osteoblasts constitute a regulatory network that mediates development of the bone phenotype through the sequential association of distinct HD proteins with promoter regulatory elements.

TL;DR: The results suggest that the loss of the C-terminal domain of AML-1B is a frequent consequence of the leukemia-related t(8; 21) and t(3;21) translocations and may be functionally linked to the modified interrelationships between nuclear structure and gene expression characteristic of cancer cells.

TL;DR: Functional contributions of 5′ regulatory sequences conserved in rat, mouse and human CBFA1 genes to transcription are defined and indicate that the CB FA1 gene is autoregulated in part by negative feedback on its own promoter to stringently controlCBFA1 gene expression and function during bone formation.

TL;DR: The results support the concept that the nuclear matrix mediates osteoblast-specific expression of the osteocalcin gene and indicate that AML family members may selectively partition between nuclear matrix and nonmatrix compartments.