Hannah D. G. Fiji

TL;DR: Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein Geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes.

TL;DR: The identification and characterization of small molecule inhibitors of GGTase-I (GGTI) with two novel scaffolds from a library consisting of allenoate-derived compounds and the discovery of a common structural feature for RabGGTase inhibitors: the presence of a characteristic six-atom aliphatic tail attached to the penta-substituted pyrrolidine core.

TL;DR: In vivo effects of the novel GGTI compound P61A6 are investigated by using a human pancreatic cancer xenograft model in mice and show an excellent antitumor effect, providing evidence that protein GGTase-I may be a valid target for cancer therapy.

TL;DR: A critical modulatory role for VDAC2-dependent mitochondrial Ca2+ uptake in the regulation of cardiac rhythmicity is demonstrated and efsevin is identified based on its potent activity to restore coordinated contractions in tremblor.

TL;DR: It is shown that the caudal vein plexus in zebrafish forms by endothelial cell sprouting, migration and anastomosis, providing a venous-specific angiogenesis model, and multiple lines of evidence indicate that aplexone differentially regulates arteriovenousAngiogenesis by targeting the HMG-CoA reductase (HMGCR) pathway.