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Hans E. Junginger

Researcher at Leiden University

Publications -  211
Citations -  16616

Hans E. Junginger is an academic researcher from Leiden University. The author has contributed to research in topics: Stratum corneum & Vesicle. The author has an hindex of 72, co-authored 211 publications receiving 15904 citations. Previous affiliations of Hans E. Junginger include Hebrew University of Jerusalem & Naresuan University.

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Oral drug absorption enhancement by chitosan and its derivatives.

TL;DR: Mono-carboxymethylated chitosan (MCC) is a polyampholytic polymer, able to form visco-elastic gels in aqueous environments or with anionic macromolecules at neutral pH values, and appears to be less potent compared to the quaternized derivative.
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Chitosan and its derivatives in mucosal drug and vaccine delivery

TL;DR: From the studies reviewed it is concluded that chitosan and chitOSan derivatives are promising polymeric excipients for mucosal drug and vaccine delivery.
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The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro

TL;DR: A threshold value of about 50% of TEER reduction has been identified, which allows for transport of hydrophilic compounds across the cell monolayers of the Caco-2 cell model.
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Preparation and NMR characterization of highly substitutedN-trimethyl chitosan chloride

TL;DR: In this paper, a two-and three-stage N,N,N-Trimethyl chitosan chloride (TMC) was synthesized using methyl iodide as reagent.
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Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system.

TL;DR: In vivo uptake studies indicated the transport of FITC-albumin-loaded TMC nanoparticles by nasal epithelia tissue in rats was studied, indicating a potential new delivery system for transport of proteins through the nasal mucosa.