J. Coos Verhoef

TL;DR: From the studies reviewed it is concluded that chitosan and chitOSan derivatives are promising polymeric excipients for mucosal drug and vaccine delivery.

TL;DR: A threshold value of about 50% of TEER reduction has been identified, which allows for transport of hydrophilic compounds across the cell monolayers of the Caco-2 cell model.

TL;DR: Several approaches are discussed to increase the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption, however, more experimental evidence is needed to support the conclusion that this improved absorption is caused by a longer residenceTime of the nasal drug formulation.

TL;DR: The mucoadhesive polymers carbomer 934P and chitosan hydrochloride are able to enhance the intestinal absorption of buserelin in vivo in rats, and may therefore be promising excipients in peroral delivery systems for peptide drugs.

TL;DR: It is concluded from this study that the charge, charge density and the structural features of chitosans and chitOSan derivatives are important factors determining their potential use as absorption enhancers.