Harald John

TL;DR: By means of reverse pharmacology screening using a peptide library generated from human hemofiltrate, TIG2 is isolated and identified as the natural ligand of ChemR23 and report the specific molecular form of the bioactive, circulating Tig2, representing the amino‐acid residues 21 to 154 of the 163 amino acid‐containing prepropeptide.

TL;DR: Procedures based on LC–MS techniques for quantitative determination of peptides are reviewed using numerous examples from the literature, complemented by experiments and results from the laboratory.

TL;DR: Experimental results provided unambiguous evidence for a systemic intoxication and were the first proving the use of sarin in the ongoing bellicose conflict, highlighting the requirement for qualified and specialized analytical laboratories to face repeated violation of the Chemical Weapons Convention.

TL;DR: LC-MS-MS detection of phosphylated peptides generated from inhibited circulating serum butyrylcholinesterase by valuable proteomics techniques enables proof of intoxication on the molecular level, and a comprehensive overview on the status quo of LC- MS-based OPC analysis is given.

TL;DR: Results indicate that solvents play a crucial role in dimethoate toxicity and reformulation of OP insecticides to ensure that the agricultural product has lower mammalian toxicity could result in fewer deaths after suicidal ingestion and rapidly reduce global suicide rates.