Harihara Baskaran

TL;DR: A critical role for mechanical force is demonstrated in adult tendon homeostasis and this mechanism could translate physical force into biochemical signals in a much broader variety of tissues or systems in the body.

TL;DR: The design of nanoparticles strongly affects their margination, a key factor for their ultimate in vivo effectiveness, and the particle density showed an even more essential role, as it was observed that the lighter particles marginated significantly more.

TL;DR: A chain-shaped nanoparticle for vascular targeting based on an α(v)β(3) integrin-targeted nanochain particle composed of four iron oxide nanospheres chemically linked in a linear assembly showed high specificity in a highly aggressive breast tumor model in mice.

TL;DR: Non-muscle myosin IIB plays a major role in applying force on the nucleus to facilitate nuclear translocation through tight spaces during 3D invasive migration, while non-muscles in the nucleus are critical for generating force during active protrusion.

TL;DR: The results show that, under the conditions tested, hMSCs were quantitatively and homogeneously loaded into the scaffolds with 90+% retention rates after 24 h in perfusion culture with no negative effect on cell viability or chondrogenic potential.