H
Harry F. Dovey
Researcher at Stanford University
Publications - 9
Citations - 4307
Harry F. Dovey is an academic researcher from Stanford University. The author has contributed to research in topics: P3 peptide & Protease. The author has an hindex of 6, co-authored 9 publications receiving 4217 citations.
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Journal ArticleDOI
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
Peter Seubert,Carmen Vigo-Pelfrey,Frederick Esch,Michael K. Lee,Harry F. Dovey,Dave Davis,Sukanto Sinha,Michael Schiossmacher,Justine Whaley,Cathy Swindlehurst,Robert T. McCormack,Robert L. Wolfert,Dennis J. Selkoe,Ivan Lieberburg,Dale Schenk +14 more
TL;DR: It is demonstrated that Aβ is produced and released both in vivo and in vitro, and new opportunities for developing diagnostic tests for Alzheimer's disease and therapeutic strategies aimed at reducing the cerebral deposition of Aβ are offered.
Journal ArticleDOI
Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Sukanto Sinha,John P. Anderson,Robin Barbour,Guriqbal S. Basi,Russell J. Caccavello,David Davis,Minhtam Doan,Harry F. Dovey,Normand Frigon,Jin Hong,Kirsten L. Jacobson-Croak,Nancy Jewett,Pamela S. Keim,J. Knops,Ivan Lieberburg,Michael Power,Hua Tan,Gwen Tatsuno,Jay Tung,Dale Schenk,Peter Seubert,Susanna Suomensaari,Shuwen Wang,Donald A. Walker,Jun Zhao,Lisa McConlogue,Varghese John +26 more
TL;DR: A membrane-bound enzyme activity that cleaves full-length APP at the β-secretase cleavage site is described and found to be the predominant β-cleavage activity in human brain, and it is found that human brain β- secretase is a new membrane- bound aspartic proteinase.
Journal ArticleDOI
The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.
Tilman Oltersdorf,Lawrence C. Fritz,Dale Schenk,Ivan Lieberburg,Kelly Johnson-Wood,Eric C. Beattie,Pamela J. Ward,Russell W. Blacher,Harry F. Dovey,Sukanto Sinha +9 more
TL;DR: The deduced amino-terminal sequence of APP is iden-tical to the sequence of a cell-secreted protease inhibitor, protease nexin-II (PN-II)8, and it is concluded that the secreted form of APP with the Kunitz protease inhibitors domain is PN-II.
Journal ArticleDOI
Cells with a familial Alzheimer's disease mutation produce authentic beta-peptide.
TL;DR: It is suggested that this cellular system may be useful for mechanistic studies of A beta generation and possibly for the development of therapeutic agents to treat AD.
Journal ArticleDOI
Mitochondrial DNA of human-mouse cell hybrids.
David A. Clayton,David A. Clayton,Raymond L. Teplitz,Markus Nabholz,Markus Nabholz,Harry F. Dovey,Walter F. Bodmer,Walter F. Bodmer +7 more
TL;DR: It is shown that hamster–mouse hybrids synthesized both hamster and mouse ribosomal RNA, and this paper is the first to show this result in detail.