Harry Vilkman

TL;DR: The results indicate that the previously demonstrated age-related decline in striatal dopamine D2 receptors extends to several extrastriatal regions in normal human males, and the rate of D2/3R decline may be faster in the frontal cortex as compared to the temporal and thalamic regions.

TL;DR: The major finding in this study is that depressive symptoms in neuroleptic-naive first-admission schizophrenia are associated with low presynaptic dopamine function, which appears to be hemisphere-related and may have drug-treatment implications, e.g., in prediction of response to D2 receptor blocking antipsychotic drugs.

TL;DR: Women had significantly higher striatal [(18)F]fluorodopa uptake (Ki values) than men and this finding may be associated with sex differences in vulnerability and clinical course of neuropsychiatric disorders with dopaminergic dysregulation, e.g., schizophrenia, alcohol dependence, and Parkinson's disease.

TL;DR: Smoking is related to greater dopamine activity in the human basal ganglia and nicotine-induced dopamine activity may be a relevant mechanism in dependence on cigarette smoking.

TL;DR: Average striatal dopamine transporter density is unaltered in neuroleptic-naive patients with schizophrenia, however, patients lack asymmetry in caudate dopamine transporter binding, which conforms with disrupted brain lateralization in this disorder.