Journal ArticleDOI
Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
Jarmo Hietala,Erkka Syvälahti,Harry Vilkman,K. Vuorio,V. Räkköläinen,Jörgen Bergman,Merja Haaparanta,Olof Solin,Mikko Kuoppamäki,Esa Eronen,Ulla Ruotsalainen,Raimo K. R. Salokangas +11 more
TLDR
The major finding in this study is that depressive symptoms in neuroleptic-naive first-admission schizophrenia are associated with low presynaptic dopamine function, which appears to be hemisphere-related and may have drug-treatment implications, e.g., in prediction of response to D2 receptor blocking antipsychotic drugs.About:
This article is published in Schizophrenia Research.The article was published on 1999-01-04. It has received 245 citations till now. The article focuses on the topics: Fluorodopa & Dopamine receptor D2.read more
Citations
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The Dopamine Hypothesis of Schizophrenia: Version III—The Final Common Pathway
Oliver D. Howes,Shitij Kapur +1 more
TL;DR: The dopamine hypothesis of schizophrenia-version III is synthesized into a comprehensive framework that links risk factors, including pregnancy and obstetric complications, stress and trauma, drug use, and genes, to increased presynaptic striatal dopaminergic function.
Journal ArticleDOI
Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.
Anissa Abi-Dargham,Janine Rodenhiser,David Printz,Yolanda Zea-Ponce,Roberto Gil,Lawrence S. Kegeles,Richard L. Weiss,Thomas B. Cooper,J. John Mann,Ronald L. Van Heertum,Jack M. Gorman,Marc Laruelle +11 more
TL;DR: Elevated synaptic dopamine was predictive of good treatment response of positive symptoms to antipsychotic drugs and increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons.
Journal ArticleDOI
The nature of dopamine dysfunction in schizophrenia and what this means for treatment
Oliver D. Howes,Joseph Kambeitz,Euitae Kim,Daniel Stahl,Mark Slifstein,Anissa Abi-Dargham,Shitij Kapur +6 more
TL;DR: The locus of the largest dopaminergic abnormality in schizophrenia is presynaptic, which affects dopamine synthesis capacity, baseline synaptic dopamine levels, and dopamine release, and future drug development should focus on the control of presYNaptic dopamine synthesis and release capacity.
Journal ArticleDOI
Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia
Oliver D. Howes,Andrew J. Montgomery,M.-C. Asselin,Robin M. Murray,Isabel Valli,Paul Tabraham,Elvira Bramon-Bosch,Lucia Valmaggia,Louise Johns,Matthew R. Broome,Philip McGuire,Paul M. Grasby +11 more
TL;DR: Findings indicate that dopamine overactivity predates the onset of schizophrenia in individuals with prodromal psychotic symptoms, is predominantly localized in the associative striatum, and is correlated with the severity of symptoms and neurocognitive dysfunction.
Journal ArticleDOI
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia.
Andreas Meyer-Lindenberg,Robert S. Miletich,Philip Kohn,G. Esposito,Richard E. Carson,Mario Quarantelli,Daniel R. Weinberger,Karen F. Berman +7 more
TL;DR: The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities.
References
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Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
TL;DR: Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding, providing a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.
Journal ArticleDOI
Effect of chlorpromazine or haloperidol on formation of 3methoxytyramine and normetanephrine in mouse brain.
Arvid Carlsson,Margit Lindqvist +1 more
Journal ArticleDOI
Negative v positive schizophrenia. Definition and validation.
TL;DR: Criteria for dividing the schizophrenic syndrome into three subtypes was developed: positive, negative, and mixed schizophrenia, and significant differences were noted using external validators such as premorbid adjustment, indices of cognitive dysfunction, ventricular brain ratio, and course in hospital.