Hartono Candra

TL;DR: A novel mechanism whereby specialized metabolites are formed by the coupling of two biosynthetic pathways via an unprecedented in vivo Japp-Klingemann reaction is unraveled, raising the prospect of exploiting the arylamine-diazotizing enzymes (AAD) for the in vivo synthesis of aryl compounds and modification of biological macromolecules.

TL;DR: Trikoramide A is a C-prenylated cyclotryptophan-containing cyanobactin that possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 μM, respectively.

TL;DR: The authors showed that the sungeidine pathway is a "degenerative" AQE pathway that contains upstream enzymes for AQE biosynthesis, and retrofitted the Sungeidine with genes from the dynemicin pathway not only restored the biosynthesis of the AQE skeleton but also produced a series of novel compounds likely as the cycloaromatized derivatives of chemically unstable biosynthetic intermediates.

TL;DR: In this article , the authors identified a Streptomyces strain that produces balmoralmycin and seven biosynthetically related coproducts (compounds 2−8), four of which exhibited cytotoxicity against the human pancreatic cancer cell line MIA PaCa-2 with IC50 values ranging from 0.9 to 1.2 µg/mL.

TL;DR: The experimental data suggest that the production of tasikamides I-K are generated by the coupling of two biosynthetic pathways via a non-enzymatic condensation reaction between an arylamine and a β-keto aldehyde-containing precursor.