Haruhiko Soma

TL;DR: The finding of the oscillatory expression of canonical clock genes with a temporal order provides an interesting hypothesis, that cyclic timing of all clock and clock-controlled genes may be dependent on several transcriptional elements including 3 known elements, E-box, RORE, and DBPE.

TL;DR: It is shown by systematic molecular biological analysis that acute physical stress elevated only Period1 (Per1) mRNA expression in mouse peripheral organs, and results suggest that Per1 can be a potential stress marker and that a third pathway of Per1 transcriptional control may exist in addition to the clock-regulated CLOCK-BMAL1/E-box and light-responsive cAMP- responsive element-binding protein/cAMP-responsive element pathways.

TL;DR: The direct repeat of the E-box-like elements identified in this study is the minimal required element for the generation of cell-autonomous transcriptional oscillation of clock and clock-controlled genes.

TL;DR: It is shown that the circadian phase of clock gene expression in hair follicle cells accurately reflects that of individual behavioral rhythms, demonstrating that this strategy is appropriate for evaluating the human peripheral circadian clock.

TL;DR: In this article, a bio-signal measurement equipment is employed for measurement of bio signals in the head and includes a support body capable of supporting the head, and electrodes provided on the support body, which makes it possible to improve measurement accuracy without imposing an excessive burden on the subject.