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Eisuke Nishida
Researcher at Kyoto University
Publications - 360
Citations - 47662
Eisuke Nishida is an academic researcher from Kyoto University. The author has contributed to research in topics: Mitogen-activated protein kinase kinase & MAP kinase kinase kinase. The author has an hindex of 112, co-authored 349 publications receiving 45918 citations. Previous affiliations of Eisuke Nishida include Johns Hopkins University & Japan Agency for Medical Research and Development.
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Journal ArticleDOI
Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways
Hidenori Ichijo,Eisuke Nishida,Kenji Irie,Peter ten Dijke,Masao Saitoh,Tetsuo Moriguchi,Minoru Takagi,Kunihiro Matsumoto,Kohei Miyazono,Yukiko Gotoh +9 more
TL;DR: Overexpression of ASK1 induced apoptotic cell death, andASK1 was activated in cells treated with tumor necrosis factor-α, and TNF-α-induced apoptosis was inhibited by a catalytically inactive form of AsK1.
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Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
Shigeaki Kato,Hideki Endoh,Yoshikazu Masuhiro,Takuya Kitamoto,Shimami Uchiyama,Haruna Sasaki,Shoichi Masushige,Yukiko Gotoh,Eisuke Nishida,Hiroyuki Kawashima,Daniel Metzger,Pierre Chambon +11 more
TL;DR: The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1), which is modulated by the phosphorylated Ser118 through the Ras-MAPK cascade of the growth factor signaling pathways.
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Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction
Kyoko Yamaguchi,Kyoko Shirakabe,Hiroshi Shibuya,Kenji Irie,Isao Oishi,Naoto Ueno,Tadatsugu Taniguchi,Eisuke Nishida,Kunihiro Matsumoto +8 more
TL;DR: Results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.
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Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
Neng Yang,Osamu Higuchi,Kazumasa Ohashi,Kyoko Nagata,Atsushi Wada,Kenji Kangawa,Eisuke Nishida,Kensaku Mizuno,Kensaku Mizuno +8 more
TL;DR: It is shown that LIM-kinase 1 (LIMK-1), a serine/threonine kinase containing LIM and PDZ domains, phosphorylates cofilin at Ser’3, both in vitro and in vivo, which indicates that LIMK- 1 participates in Rac-mediated actin cytoskeletal reorganization, probably by phosphoryLating co Filin.
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CRM1 is responsible for intracellular transport mediated by the nuclear export signal
Makoto Fukuda,Shiro Asano,Takahiro Nakamura,Makoto Adachi,Minoru Yoshida,Mitsuhiro Yanagida,Eisuke Nishida +6 more
TL;DR: It is shown that p110 is CRM1, which is an evolutionarily conserved protein originally found as an essential nuclear protein in fission yeast and known as a likely target of LMB, which indicates that CRM 1 is an essential mediator of the NES-dependent nuclear export of proteins in eukaryotic cells.