H
Harvey C. Gonick
Researcher at University of California, Los Angeles
Publications - 90
Citations - 2986
Harvey C. Gonick is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Renal function & Ouabain. The author has an hindex of 32, co-authored 90 publications receiving 2921 citations. Previous affiliations of Harvey C. Gonick include Universidade Federal de Santa Catarina & West Los Angeles College.
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Lead-Induced Hypertension: Interplay of Nitric Oxide and Reactive Oxygen Species
TL;DR: The data suggest a balance between increased NO synthesis and degradation (by reactive oxygen species) in lead-treated rats, which results in normal levels of NO.
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Lead promotes hydroxyl radical generation and lipid peroxidation in cultured aortic endothelial cells.
TL;DR: It is demonstrated that lead exposure promotes hydroxyl radical generation and induces oxidative stress in isolated endothelial cells, mimicking the effects observed in lead-exposed animals.
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Lead-induced hypertension: possible role of endothelial factors.
Farhad Khalil-Manesh,Harvey C. Gonick,Elmar W. J. Weiler,Bruce A. Prins,Michael A. Weber,Ralph E. Purdy +5 more
TL;DR: The path to development of hypertension in low lead rats may be through an increase in the concentration of the vasoconstrictor hormone, ET-3, and a decrease in the vasodilator hormone, EDRF.
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Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: Effect of lazaroid therapy
TL;DR: Administration of the potent antioxidant, lazaroid, abrogated HTN and reversed the abnormalities of plasma MDA and urinary NOx excretion, thus supporting the role of ROS in lead-induced HTN in this model.
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Simultaneous measurement of marinobufagenin, ouabain, and hypertension-associated protein in various disease states.
TL;DR: Only the 12 kD HAP band possessed all of the attributes of natriuretic hormone after extraction of the bands, with essentially no activity found in the 14 kD or 21 kD bands.