Showing papers in "American Journal of Hypertension in 1993"

TL;DR: According to this hypothesis, essential hypertension, insulin resistance, hyperinsulinemia, and NIDDM are in reality different clinical components of what should be better designated as "generalized cardiovascular-metabolic disease" (GCMD).

TL;DR: No significant correlations were found between the plasma ET-1 levels and Hct, time on dialysis and rHuEPO doses, and the antihypertensive therapeutic index (ATI).

TL;DR: The path to development of hypertension in low lead rats may be through an increase in the concentration of the vasoconstrictor hormone, ET-3, and a decrease in the vasodilator hormone, EDRF.

TL;DR: For patients with coronary bypass grafts, differences in endothelium-derived vasoactive factors between the internal mammary artery and the saphenous vein may be important determinants of graft function, with the mammary arteries having more pronounced relaxations than the sa phenous vein and thus a higher patency rate.

TL;DR: The results of epidemiologic studies suggest that the elevated fasting and postprandial insulin levels that often occur in patients with essential hypertension, as well as in Patients with type II diabetes mellitus, are an independent risk factor for atherosclerotic cardiovascular disease.

TL;DR: As the absence of a nocturnal BP fall has been associated with the increased prevalence of left ventricular hypertrophy and atherosclerotic cardiovascular disease, its detection by ambulatory monitoring might be of prognostic and therapeutic importance.

TL;DR: Non-dippers, in whom the normal nocturnal fall of pressure is diminished, have been reported to show more target organ damage than dippers, which may be explained by a higher average 24 h BP.

TL;DR: In multivariate analyses, systolic blood pressure, age, and race were consistently predictors of increased LV mass and abnormal cardiac geometry and cholesterol level was not independently associated with increased LVmass but was weakly associated withIncreased relative wall thickness.

TL;DR: The results suggest that losartan has a long-acting hypotensive effect with a hypouricemic action in essential hypertension.

TL;DR: The genetic and environmental determinants of hypertension, lipid abnormalities, and coronary artery disease (CAD) have been studied for 15 years in Utah in population-based multigenerational pedigrees, and single-gene effects were found for several 'intermediate phenotypes' associated with hypertension.

TL;DR: Patients with a diastolic blood pressure over 90 mm Hg were recruited from a running health screening program to participate in a double blind cross-over study of magnesium supplementation (15 mmol Mg2+/day (Emgesan, Kabi Pharmacia) for 3 weeks) and a significant decrease in the mean systolicBlood pressure was recorded.

TL;DR: The results indicate that an increase in central sympathetic drive plays an important role in the hypertension induced by chronic inhibition of nitric oxide synthesis with L-NAME.

TL;DR: It is suggested that the altered expression of G-proteins may partly be responsible for the decreased responsiveness of adenylyl cyclase to hormone stimulation and increased responsiveness to hormone inhibition in DOCA-salt hypertension.

TL;DR: Hyperglycemia per se elevates Cai and suppresses Mgi and pHi in normal human red cells and was dose dependent, significant elevations in Cai being observed at 10 and 15 mmol/L, but not at the other concentrations tested.

TL;DR: The congruity of two different approaches for the assessment of salt responsivity of blood pressure in humans is demonstrated with significant correlation between the blood pressure responses to the separate techniques in the same individual.

TL;DR: Comparison of drug administration with the evening meal or at bedtime revealed no significant differences in either the extent of bioavailability (area under the curve; AUC) or pharmacodynamic effect [reduction in low-density lipoprotein cholesterol (LDL-C)].

TL;DR: Findings suggest that, in addition to blood pressure, volume and/or humoral factors influence the pathogenesis of left ventricular hypertrophy and its reversibility.

TL;DR: White coat hypertensive patients display less cardiac involvement than patients with established hypertension, indicating that they should rather be treated as normotensives than as hypertensives, ie, not with pharmacological antihypertensive therapy.

TL;DR: Chronic elevations in plasma aldosterone, relative to dietary sodium intake, do not have a direct cytotoxic effect on cardiac myocytes, but they are associated with a reactive interstitial fibrosis, which is thought to be related to MC excess.

TL;DR: There is strong evidence of early cardiac morphologic changes and altered peripheral vascular capacity and responsivity to pressor stimuli among normotensive individuals with a positive family history, but cardiac output, sodium consumption, intravascular volume, and cardiovascular responses to isometric exercise and standing do not differ in persons with and without a family history of hypertension.

TL;DR: Comparison of patients with concentric LV hypertrophy, the LV pattern associated with the worst prognosis, with normotensive subjects with normal LV geometry suggests that awake ABPs in adults below 139/86mm Hg might be considered normal, whereas values over 149/95 mm Hgmight be considered pathologic.

TL;DR: Findings with normotensive children corroborate other findings that have typically involved hypertensive children, indicating that resting heart rate and systolic pressure, gender, and adiposity are early determinants of LVM indices in children.

TL;DR: It is concluded that because of the significant interaction between activity and blood pressure, ABPM data should be interpreted only in the light of concomitant activity data.

TL;DR: Changes in insulin regulation of Na+,K(+)-ATPase gene expression in vascular smooth muscle may be an important factor in the development of hypertension in diabetes.

TL;DR: The dense distribution of C GRP-rich structures and the expression of mRNA in the central nervous system suggests that CGRP has a neuromodulator or neurotransmitter role not limited to vasoregulatory effects only, but like calcitonin, extends its action to physiologic, metabolic, and behavioral functions.

TL;DR: Observations confirm the heterogeneity of blood pressure response to calcium supplementation and demonstrate congruity between sodium and calcium responsiveness ofBlood pressure in normal and hypertensive humans.

TL;DR: It is concluded that pill counts tend to overestimate patients' compliance rates, changes in medication-taking behavior early in therapy may predict subsequent compliance rates; and prolonging drug action may compensate for some imperfect medication- taking behavior.

TL;DR: It is concluded that in certain genetic backgrounds the SA gene (or a closely linked gene) can contribute a significant component of genetic hypertension.

TL;DR: There may be racial differences in adrenergic receptor mechanisms involved in the pathogenesis of hypertension, as seen in black and white borderline hypertensive and normotensive men.

TL;DR: The increased LVMI the authors observed may represent a possible link between diabetic autonomic neuropathy, nocturnal blood pressure levels, and higher cardiovascular mortality rate.