H
Hassanul G. Choudhury
Researcher at Rutherford Appleton Laboratory
Publications - 15
Citations - 585
Hassanul G. Choudhury is an academic researcher from Rutherford Appleton Laboratory. The author has contributed to research in topics: ATP-binding cassette transporter & Peptide. The author has an hindex of 12, co-authored 15 publications receiving 504 citations. Previous affiliations of Hassanul G. Choudhury include University of Queensland & Imperial College London.
Papers
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Journal ArticleDOI
Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state.
Hassanul G. Choudhury,Zhen Tong,Indran Mathavan,Yanyan Li,So Iwata,Séverine Zirah,Sylvie Rebuffat,Hendrik W. van Veen,Konstantinos Beis,Konstantinos Beis +9 more
TL;DR: The crystal structure of McjD from Escherichia coli is determined, which is to the authors’ knowledge the first structure of an antibacterial peptide ABC transporter, and it is proposed that the outward-occluded state represents a transition intermediate between the inward- open and inward-open conformation of ABC exporters.
Journal ArticleDOI
Functional Characterization of SbmA, a Bacterial Inner Membrane Transporter Required for Importing the Antimicrobial Peptide Bac7(1-35)
Giulia Runti,Maria del Carmen Lopez Ruiz,Maria del Carmen Lopez Ruiz,Tatiana Stoilova,Rohanah Hussain,Matthew Jennions,Matthew Jennions,Hassanul G. Choudhury,Hassanul G. Choudhury,Monica Benincasa,Renato Gennaro,Konstantinos Beis,Konstantinos Beis,Marco Scocchi +13 more
TL;DR: Functional features of SbmA/BacA are investigated using the proline-rich antimicrobial peptide Bac7(1-35) as a substrate and results suggest that the transport of an unknown substrate(s) represents the function of this protein.
Journal ArticleDOI
Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides.
Indran Mathavan,Séverine Zirah,Shahid Mehmood,Hassanul G. Choudhury,Christophe Goulard,Yanyan Li,Carol V. Robinson,Sylvie Rebuffat,Konstantinos Beis +8 more
TL;DR: The lasso peptide microcin J25 is known to hijack the siderophore receptor FhuA for initiating internalization and the first structural evidence on the recognition mechanism is provided and biochemical data show that another closely related lasso Peptide cannot interact with F HuA.
Journal ArticleDOI
Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD.
Kiran Bountra,Kiran Bountra,Gregor Hagelueken,Hassanul G. Choudhury,Hassanul G. Choudhury,Valentina Corradi,Kamel El Omari,Armin Wagner,Indran Mathavan,Indran Mathavan,Séverine Zirah,Weixiao Yuan Wahlgren,Weixiao Yuan Wahlgren,Weixiao Yuan Wahlgren,D. Peter Tieleman,Olav Schiemann,Sylvie Rebuffat,Konstantinos Beis,Konstantinos Beis +18 more
TL;DR: A novel mechanism for toxic peptide ABC exporters that only requires the transient opening of the cavity for release of the peptide, preventing toxic‐level build‐up is proposed.
Journal ArticleDOI
Structure determination of an integral membrane protein at room temperature from crystals in situ
Danny Axford,James Foadi,Nien-Jen Hu,Nien-Jen Hu,Hassanul G. Choudhury,Hassanul G. Choudhury,So Iwata,Konstantinos Beis,Konstantinos Beis,Gwyndaf Evans,Yilmaz Alguel,Yilmaz Alguel +11 more
TL;DR: The X-ray structure determination of an integral membrane protein using synchrotron diffraction data measured in situ at room temperature is demonstrated.