D
Danny Axford
Publications - 64
Citations - 2028
Danny Axford is an academic researcher. The author has contributed to research in topics: Diffraction & Medicine. The author has an hindex of 20, co-authored 54 publications receiving 1701 citations.
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Journal ArticleDOI
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71
Xiangxi Wang,Wei Peng,Jingshan Ren,Zhongyu Hu,Jiwei Xu,Zhiyong Lou,Xumei Li,Weidong Yin,Xinliang Shen,Claudine Porta,Thomas S. Walter,Gwyndaf Evans,Danny Axford,Robin L. Owen,David J. Rowlands,Junzhi Wang,David I. Stuart,Elizabeth E. Fry,Zihe Rao,Zihe Rao +19 more
TL;DR: These structures provide a model for enterovirus uncoating in which the VP1 GH loop acts as an adaptor-sensor for cellular receptor attachment, converting heterologous inputs to a generic uncoated mechanism, highlighting new opportunities for therapeutic intervention.
Journal ArticleDOI
Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography
James Foadi,Pierre Aller,Yilmaz Alguel,Alexander D. Cameron,Danny Axford,Robin L. Owen,Wes Armour,David G. Waterman,So Iwata,Gwyndaf Evans +9 more
TL;DR: A systematic approach to the scaling and merging of data from multiple crystals in macromolecular crystallography is introduced and explained.
Journal ArticleDOI
Picornavirus uncoating intermediate captured in atomic detail
Jingshan Ren,Xiangxi Wang,Zhongyu Hu,Qiang Gao,Yao Sun,Xuemei Li,Claudine Porta,Thomas S. Walter,Robert J.C. Gilbert,Yuguang Zhao,Danny Axford,Mark Williams,Katherine McAuley,David J. Rowlands,Weidong Yin,Junzhi Wang,David I. Stuart,Zihe Rao,Zihe Rao,Zihe Rao,Elizabeth E. Fry +20 more
TL;DR: The atomic structure of an uncoating intermediate for the major human picornavirus pathogen CAV16 is presented, which reveals VP1 partly extruded from the capsid, poised to embed in the host membrane.
Journal ArticleDOI
In situ macromolecular crystallography using microbeams.
Danny Axford,Robin L. Owen,Jun Aishima,James Foadi,Ann W. Morgan,James I. Robinson,Joanne E. Nettleship,Raymond J. Owens,Isabel Moraes,Elizabeth E. Fry,Jonathan M. Grimes,Karl Harlos,Abhay Kotecha,Jingshan Ren,Geoff Sutton,Thomas S. Walter,David I. Stuart,Gwyndaf Evans +17 more
TL;DR: A sample environment for mounting crystallization trays has been developed on the microfocus beamline I24 at Diamond Light Source and several case studies are described.
Journal ArticleDOI
How baculovirus polyhedra fit square pegs into round holes to robustly package viruses
TL;DR: The structure of polyhedra of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is determined, revealing a highly symmetrical covalently cross‐braced robust lattice, the subunits of which possess a flexible adaptor enabling this supra‐molecular assembly to specifically entrap massive bacULoviruses.