S
Séverine Zirah
Researcher at Centre national de la recherche scientifique
Publications - 72
Citations - 2183
Séverine Zirah is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Peptide & Biology. The author has an hindex of 23, co-authored 65 publications receiving 1783 citations. Previous affiliations of Séverine Zirah include University of Paris & National Museum of Natural History.
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Journal ArticleDOI
Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.
Séverine Zirah,Sergey A. Kozin,Alexey K. Mazur,Alain Blond,Michel Cheminant,Isabelle Ségalas-Milazzo,Pascale Debey,Sylvie Rebuffat +7 more
TL;DR: The solution structure of the Aβ-(1-16)-Zn2+ complex in aqueous solution at pH 6.5 was determined from NMR data and the potentiality of the region 1-16 of Aβ to be used as a therapeutic target was identified.
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Isolation and Characterization of Environmental Bacteria Capable of Extracellular Biosorption of Mercury
Fabienne François,Carine Lombard,Jean-Michel Guigner,Paul Soreau,Florence Brian-Jaisson,Grégory Martino,Manon Vandervennet,Daniel Garcia,Anne-Laure Molinier,David Pignol,Jean Peduzzi,Séverine Zirah,Sylvie Rebuffat +12 more
TL;DR: Seven strains of Hg-tolerant bacteria tolerant to mercury were shown to produce EPS, which were characterized by Fourier transform-infrared (FT-IR) spectroscopy and chemical analysis of neutral-carbohydrate, uronic acid, and protein contents.
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Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state.
Hassanul G. Choudhury,Zhen Tong,Indran Mathavan,Yanyan Li,So Iwata,Séverine Zirah,Sylvie Rebuffat,Hendrik W. van Veen,Konstantinos Beis,Konstantinos Beis +9 more
TL;DR: The crystal structure of McjD from Escherichia coli is determined, which is to the authors’ knowledge the first structure of an antibacterial peptide ABC transporter, and it is proposed that the outward-occluded state represents a transition intermediate between the inward- open and inward-open conformation of ABC exporters.
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Two enzymes catalyze the maturation of a lasso peptide in Escherichia coli
Sophie Duquesne,Delphine Destoumieux-Garzón,Séverine Zirah,Christophe Goulard,Jean Peduzzi,Sylvie Rebuffat +5 more
TL;DR: It is demonstrated that McjB and McjC, encoded by genes in the MccJ25 gene cluster, catalyze the maturation of MCCJ25, and it is shown that putative lasso peptides are widespread among Proteobacteria and Actinobacteria.
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Dissecting the maturation steps of the lasso peptide microcin J25 in vitro.
Kok-Phen Yan,Yanyan Li,Séverine Zirah,Christophe Goulard,Thomas A. Knappe,Mohamed A. Marahiel,Sylvie Rebuffat +6 more
TL;DR: Different functions of McjB and McjC in vitro for the first time are demonstrated based on the detection of reaction intermediates, which indicates that microcin J25 variants with either a lasso or branched‐cyclic topology could be generated in vitro.