H
Hatem H. Salem
Researcher at Monash University
Publications - 101
Citations - 5682
Hatem H. Salem is an academic researcher from Monash University. The author has contributed to research in topics: Protein C & Platelet. The author has an hindex of 39, co-authored 101 publications receiving 5432 citations. Previous affiliations of Hatem H. Salem include Washington University in St. Louis & French Institute of Health and Medical Research.
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Journal ArticleDOI
PI 3-kinase p110β: a new target for antithrombotic therapy
Shaun P. Jackson,Simone M. Schoenwaelder,Isaac Goncalves,Warwick Scott Nesbitt,Cindy L. Yap,Christine E. Wright,Vijaya Kenche,Karen E. Anderson,Sacha M Dopheide,Yuping Yuan,Sharelle Anne Sturgeon,Hishani Prabaharan,Philip E. Thompson,Gregg D Smith,Peter R. Shepherd,Nathalie Daniele,Suhasini Kulkarni,Belinda M. Abbott,Dilek Saylik,Catherine Jones,Lucy Lu,Simon Giuliano,Sascha Claire Hughan,James A. Angus,Alan D. Robertson,Hatem H. Salem +25 more
TL;DR: This study has defined a key role for the Type Ia phosphoinositide 3-kinase (PI3K) p110β isoform in regulating the formation and stability of integrin αIIbβ3 adhesion bonds, necessary for shear activation of platelets, as an important new target for antithrombotic therapy.
Journal ArticleDOI
Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis.
TL;DR: Vitamin K1 should be given in a dose that will quickly lower the INR to a safe, but not subtherapeutic, range and will not cause resistance once warfarin is reinstated.
Journal Article
Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.
TL;DR: Data show that APC inhibits host cytokine production but maintains MO responses associated with adhesion, phagocytosis, and killing of Gram-negative bacteria, such that use of APC may be a logical and potent adjunctive therapy in select inflammatory diseases involving MO activation and damagingHost cytokine overproduction.
Journal ArticleDOI
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
Simone M. Schoenwaelder,Yuping Yuan,Emma C. Josefsson,Michael J. White,Yu Yao,Kylie D. Mason,Lorraine A. O'Reilly,Katya J. Henley,Akiko Ono,Sarah Tzu-Feng Hsiao,Abbey Willcox,Andrew W. Roberts,David C.S. Huang,Hatem H. Salem,Benjamin T. Kile,Shaun P. Jackson +15 more
TL;DR: 2 distinct pathways regulating the procoagulant function of platelets are shown, one of which is Bak/Bax- and caspase-dependent and the other is agonist-induced, which was completely eliminated by extracellular calcium chelators or inhibitors of platelet activation.
Journal ArticleDOI
Intradermal Influenza Vaccine Administered Using a New Microinjection System Produces Superior Immunogenicity in Elderly Adults: A Randomized Controlled Trial
David Holland,Robert Booy,Ferdinandus de Looze,Peter Eizenberg,James McDonald,Jeff Karrasch,Maureen McKeirnan,Hatem H. Salem,Graham Mills,Jim Reid,Françoise Weber,Melanie Saville +11 more
TL;DR: For the first time, the intradermal vaccination route has been used to elicit immune responses significantly superior to those noted in association with the conventional intramuscular vaccination route, expected to enhance annual protection against influenza in this vulnerable population.