Shane T. Grey

TL;DR: It is shown that the expression of the HO-1 gene is functionally associated with xenograft survival, and that rapid expression ofHO-1 in cardiac xenografteds can be essential to ensure long-term xenogRAFT survival.

TL;DR: An in vivo approach for inducing rapid expansion of T reg cells by injecting mice with interleukin (IL)-2 mixed with a particular IL-2 monoclonal antibody (mAb) complexes, which has clinical potential for treating autoimmune disease and promoting organ transplantation.

TL;DR: It is demonstrated that endogenously produced mitochondrial superoxide activates UCP2-mediated proton leak, thus lowering ATP levels and impairing glucose-stimulated insulin secretion, and superoxide levels are increased further in the absence of U CP2, demonstrating that the adverse effects of superoxide on beta cell glucose sensing are caused by activation of UCP1.

TL;DR: Autoimmunity in BAFF Tg mice results from altered B cell tolerance, but requires TLR signaling and is independent of T cell help, and it is possible that SLE patients with elevated levels of BAFF show a similar basis for disease.

TL;DR: Several lines of evidence supporting a role of ATF3 in stress-induced β-cell apoptosis are described, and results suggest ATF3 to be a novel regulator of stress- induced β- cell apoptosis.