H
Hayley J. Newton
Researcher at University of Melbourne
Publications - 70
Citations - 3188
Hayley J. Newton is an academic researcher from University of Melbourne. The author has contributed to research in topics: Coxiella burnetii & Legionella pneumophila. The author has an hindex of 25, co-authored 63 publications receiving 2728 citations. Previous affiliations of Hayley J. Newton include Yale University & Monash University, Clayton campus.
Papers
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Journal ArticleDOI
Interaction between autophagic vesicles and the Coxiella-containing vacuole requires CLTC (clathrin heavy chain).
TL;DR: This investigation provides a functional link between CLTC and autophagy in the context of Coxiella infection and highlights the CCV as an important tool to explore the interactions between these vesicular trafficking pathways.
Journal ArticleDOI
Significant role for ladC in initiation of Legionella pneumophila infection.
Hayley J. Newton,Fiona M. Sansom,Fiona M. Sansom,Jenny Dao,Christel Cazalet,Holger Brüggemann,Christiane Albert-Weissenberger,Carmen Buchrieser,Nicholas P. Cianciotto,Elizabeth L. Hartland,Elizabeth L. Hartland +10 more
TL;DR: It is established that LadC plays an important role in L. pneumophila infection, and the mechanism by which LadC modulates the initial interaction between the bacterium and host cell remains unclear.
Journal ArticleDOI
Interfering with Autophagy: The Opposing Strategies Deployed by Legionella pneumophila and Coxiella burnetii Effector Proteins.
TL;DR: The effector proteins that Legionella pneumophila and Coxiella burnetii utilize to modulate the host autophagy pathway in order to survive and replicate are explored.
Journal ArticleDOI
The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii
TL;DR: How these bacterial species, which utilize divergent strategies to establish replicative vacuoles, use translocated proteins to manipulate host Rabs is covered, as well as exploring which Rabs are implicated in vacuolar biogenesis in these two organisms.
Book ChapterDOI
Beginning to Understand the Role of the Type IV Secretion System Effector Proteins in Coxiella burnetii Pathogenesis.
TL;DR: The development of an axenic culture medium, together with the implementation of bioinformatics tools and high-content screening approaches, have significantly progressed C. burnetii research in the last decade, and facilitated identification of the Dot/Icm type IV secretion system (T4SS) as an essential virulence factor.