H
Hayley J. Newton
Researcher at University of Melbourne
Publications - 70
Citations - 3188
Hayley J. Newton is an academic researcher from University of Melbourne. The author has contributed to research in topics: Coxiella burnetii & Legionella pneumophila. The author has an hindex of 25, co-authored 63 publications receiving 2728 citations. Previous affiliations of Hayley J. Newton include Yale University & Monash University, Clayton campus.
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Journal ArticleDOI
Coxiella burnetii: turning hostility into a home
TL;DR: A surprisingly high number of effector mutants demonstrate significant intracellular growth defects, and future studies on the molecular function of these effectors will provide great insight into the pathogenesis of Coxiella.
Journal ArticleDOI
Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.
Fiona M. Sansom,Patrice Riedmaier,Hayley J. Newton,Hayley J. Newton,Michelle A. Dunstone,Christa E. Müller,Holger Stephan,Emma Byres,Travis Clarke Beddoe,Jamie Rossjohn,Peter J. Cowan,Peter J. Cowan,Anthony J F D'Apice,Anthony J F D'Apice,Simon C. Robson,Elizabeth L. Hartland,Elizabeth L. Hartland +16 more
TL;DR: The kinetic studies undertaken here demonstrated important differences to mammalian NTPDases and different sensitivities to NTPDase inhibitors that may reflect underlying structural variations.
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SopF, a phosphoinositide binding effector, promotes the stability of the nascent Salmonella-containing vacuole.
Nicole Lau,Nicole Lau,Amanda L. Haeberle,Brittany J O'Keeffe,Eleanor A Latomanski,Jean Celli,Hayley J. Newton,Leigh A. Knodler,Leigh A. Knodler +8 more
TL;DR: The structure-function analysis shows that the carboxy-terminal seven amino acids of SopF are essential for its membrane association in host cells and to promote SCV membrane stability.
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Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole
Lara J. Kohler,Shawna C. O. Reed,Shireen A. Sarraf,David D. Arteaga,Hayley J. Newton,Craig R. Roy +5 more
TL;DR: C. burnetii residence in an autolysosomal organelle alters host tolerance of infection, which indicates that Cig2-dependent manipulation of a lysosome-derived vacuole influences the host response to infection.
Journal ArticleDOI
Contribution of Long Polar Fimbriae to the Virulence of Rabbit-Specific Enteropathogenic Escherichia coli
Hayley J. Newton,Joan Sloan,Vicki Bennett-Wood,Vicki Bennett-Wood,L M Adams,L M Adams,Roy M. Robins-Browne,Roy M. Robins-Browne,Elizabeth L. Hartland,Elizabeth L. Hartland,Elizabeth L. Hartland +10 more
TL;DR: It is suggested that lpfR141 contributes to the early stages of REPEC-mediated disease and that this is important for the development of severe diarrhea in susceptible animals.