H
Hays Arnold
Publications - 9
Citations - 2028
Hays Arnold is an academic researcher. The author has contributed to research in topics: Placebo-controlled study & Placebo. The author has an hindex of 8, co-authored 9 publications receiving 1619 citations.
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Journal ArticleDOI
Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease
TL;DR: An easily calculated score based on readily available clinical data can reliably exclude the presence of advanced fibrosis in patients with NAFLD, particularly among non-diabetics.
Journal ArticleDOI
The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial
Rohit Loomba,Eric Lawitz,Parvez S. Mantry,Saumya Jayakumar,Stephen H. Caldwell,Hays Arnold,Anna Mae Diehl,C. Stephen Djedjos,Ling Han,Robert P. Myers,G. Mani Subramanian,John G. McHutchison,Zachary Goodman,Nezam H. Afdhal,Michael Charlton +14 more
TL;DR: Selonsertib may reduce liver fibrosis in patients with nonalcoholic steatohepatitis and stage 2‐3 fibrosis and there were no significant differences in adverse events between the treatment groups.
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NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
Stephen A. Harrison,Mary E. Rinella,Manal F. Abdelmalek,James F. Trotter,Angelo H. Paredes,Hays Arnold,Marcelo Kugelmas,Mustafa R. Bashir,Mark J. Jaros,Lei Ling,Stephen J. Rossi,Alex M. DePaoli,Rohit Loomba +12 more
TL;DR: NGM282 produced rapid and significant reductions in liver fat content with an acceptable safety profile in patients with non-alcoholic steatohepatitis.
Journal ArticleDOI
NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
Stephen A. Harrison,Mary E. Rinella,Manal F. Abdelmalek,James F. Trotter,Angelo H. Paredes,Hays Arnold,Marcelo Kugelmas,Mustafa R. Bashir,Mark J. Jaros,ing L,Stephen J. Rossi,Alex M. DePaoli,Rohit Loomba +12 more
Journal ArticleDOI
Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib.
Saumya Jayakumar,Michael S. Middleton,Eric Lawitz,Parvez S. Mantry,Stephen H. Caldwell,Hays Arnold,Anna Mae Diehl,Reem Ghalib,Magdy Elkhashab,Manal F. Abdelmalek,Kris V. Kowdley,C. Stephen Djedjos,Ren Xu,Ling Han,G. Mani Subramanian,Robert P. Myers,Zachary Goodman,Nezam H. Afdhal,Michael Charlton,Claude B. Sirlin,Rohit Loomba +20 more
TL;DR: Preliminary data support the further evaluation of MRE-stiffness and MRI-PDFF for the longitudinal assessment of histologic response in patients with NASH and suggest they could potentially replace liver biopsy in evaluating NASH-related liver injury.