H
Heather A. Himburg
Researcher at University of California, Los Angeles
Publications - 66
Citations - 2369
Heather A. Himburg is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 21, co-authored 51 publications receiving 2026 citations. Previous affiliations of Heather A. Himburg include Duke University & Medical College of Wisconsin.
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Journal ArticleDOI
Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability
Heather A. Himburg,Deborah M. Grzybowski,Andrew L. Hazel,Jeffrey A. LaMack,Xue-Mei Li,Morton H. Friedman +5 more
TL;DR: A novel technique to assess the relation between fluid dynamic variables and the permeability of the endothelium to macromolecules indicates that in vivo endothelial permeability to albumin decreases with increasing time-average shear stress over the normal range.
Journal ArticleDOI
Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
Heather A. Himburg,Garrett G. Muramoto,Pamela Daher,Sarah K. Meadows,J. Lauren Russell,Phuong L. Doan,Jen-Tsan Chi,Alice B. Salter,William Lento,Tannishtha Reya,Nelson J. Chao,John P. Chute +11 more
TL;DR: It is shown that pleiotrophin, a neurite outgrowth factor with no known function in hematopoiesis, efficiently promotes HSC expansion in vitro and HSC regeneration in vivo, and is identified as a new regulator of both H SC expansion and regeneration.
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Epidermal growth factor regulates hematopoietic regeneration after radiation injury
Phuong L. Doan,Heather A. Himburg,Katherine Helms,J. Lauren Russell,Emma Fixsen,Mamle Quarmyne,Jeffrey R. Harris,Divino Deoliviera,Julie M. Sullivan,Nelson J. Chao,Nelson J. Chao,David G. Kirsch,John P. Chute,John P. Chute +13 more
TL;DR: Findings show that EGFR signaling regulates HSC regeneration after myelosuppressive injury, and EGF reduced radiation-induced apoptosis of HSCs and mediated this effect through repression of the proapoptotic protein PUMA.
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Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo.
Alice B. Salter,Sarah K. Meadows,Garrett G. Muramoto,Heather A. Himburg,Phuong L. Doan,Pamela Daher,Lauren Russell,Benny J. Chen,Nelson J. Chao,John P. Chute +9 more
TL;DR: It is demonstrated that allogeneic EPC infusions can augment hematopoiesis and suggest a relationship between BM microvascular recovery and he matopoietic reconstitution in vivo.
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Frequency-dependent response of the vascular endothelium to pulsatile shear stress
TL;DR: This study suggests that arterial regions subject to both shear reversal and dominant frequencies that exceed the normal heart rate are at greater risk for atherosclerotic lesion development.