J. Lauren Russell

TL;DR: It is shown that pleiotrophin, a neurite outgrowth factor with no known function in hematopoiesis, efficiently promotes HSC expansion in vitro and HSC regeneration in vivo, and is identified as a new regulator of both H SC expansion and regeneration.

TL;DR: Findings show that EGFR signaling regulates HSC regeneration after myelosuppressive injury, and EGF reduced radiation-induced apoptosis of HSCs and mediated this effect through repression of the proapoptotic protein PUMA.

TL;DR: PTN is a secreted component of the BM vascular niche that regulates HSC self-renewal and retention in vivo and was differentially expressed and secreted by BM sinusoidal endothelial cells within the vascular niche.

TL;DR: Pharmacologic inhibition of ALDH with diethylaminobenzaldehyde (DEAB) impeded the differentiation of murine CD34−c‐kit+Sca‐1+lineage− (34−K SL) HSCs in culture and facilitated a ninefold expansion of cells capable of radioprotecting lethally irradiated mice compared to input 34−KSL cells, suggesting that ALDH1a1 regulates HSC differentiation via augmentation of retinoid signaling

TL;DR: The hematopoietic response to ionizing radiation is dependent upon HSC‐autonomous responses but is regulated by BM EC‐mediated mechanisms, and BM ECs may be therapeutically targeted as a means to augment hematoplastic reconstitution following myelosuppression.