H
Heather A. Iocca
Researcher at University of North Carolina at Chapel Hill
Publications - 7
Citations - 966
Heather A. Iocca is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Caspase 1 & Remyelination. The author has an hindex of 7, co-authored 7 publications receiving 861 citations.
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Journal ArticleDOI
NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
Denis Gris,Zhengmao Ye,Heather A. Iocca,Haitao Wen,Robin R. Craven,Pavel Gris,Max Tze Han Huang,Monika Schneider,Stephen D. Miller,Jenny P.-Y. Ting +9 more
TL;DR: NLRP3 plays a critical role in the induction of the EAE, likely through effects on capase-1–dependent cytokines which then influence Th1 and Th17.
Journal ArticleDOI
The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18
Sushmita Jha,Siddharth Y. Srivastava,Willie June Brickey,Heather A. Iocca,Arrel D. Toews,James P. Morrison,Vivian S. Chen,Vivian S. Chen,Denis Gris,Glenn K. Matsushima,Jenny P.-Y. Ting +10 more
TL;DR: It is suggested that NLRP3 plays an important role in a model of multiple sclerosis by exacerbating CNS inflammation, and this is partly mediated by caspase-1 and IL-18.
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Criteria for effective design, construction, and gene knockdown by shRNA vectors
Dedra J. Taxman,Laura R. Livingstone,Jinghua Zhang,Brian J. Conti,Heather A. Iocca,Kristi L. Williams,John D. Lich,Jenny P.-Y. Ting,William Reed +8 more
TL;DR: An efficient method for preparing wild-type and mutant control shRNA vectors simultaneously using oligonucleotide hybrids is demonstrated and a modification based on the stability of the 6 central bases of each shRNA provides fair-to-good predictions of knockdown efficacy for three of the algorithms.
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Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways.
Debra J. Taxman,Jinghua Zhang,Catherine M. E. Champagne,Daniel T. Bergstralh,Heather A. Iocca,John D. Lich,Jenny P.-Y. Ting +6 more
TL;DR: A role for ASC is suggested in cytokine induction by Pg involving both caspase-1-dependent and -independent mechanisms, and broad applicability of these findings are indicated.
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Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses.
Brian P. O'Connor,So-Young Eun,Zhengmao Ye,Alla L. Zozulya,John D. Lich,Chris B. Moore,Heather A. Iocca,Kelly E. Roney,Eda K. Holl,Quing Ping Wu,Hendrick W. van Deventer,Zsuzsanna Fabry,Jenny P.-Y. Ting +12 more
TL;DR: A role for semaphorin 6D is revealed as a regulator of the late phase of primary immune responses, which is required during the multiphase antigen-presenting cell and T cell interactions leading to selection of long-lived lymphocytes.