William Reed

TL;DR: Air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Aβ42 and α-synuclein starting in childhood, and carriers of the APOE 4 allele could have a higher risk of developing Alzheimer’s disease if they reside in a polluted environment.

TL;DR: Morphometric analysis of the CNS indicated unequivocally that the brain is a critical target for PM Exposure and implicated oxidative stress as a predisposing factor that links PM exposure and susceptibility to neurodegeneration.

TL;DR: Exposure to severe airpollution is associated with brain inflammation and Aβ 42 accumulation, two causes of neuronal dysfunction that precede the appearance of neuritic plaques and neurofibrillary tangles, hallmarks of Alzheimer's disease.

TL;DR: There was an acceleration of Alzheimer's-type pathology in dogs chronically exposed to air pollutants, suggesting that Alzheimer's disease may be the sequela of air pollutant exposures and the resulting systemic inflammation.

TL;DR: The same acute exposure to As, V, or Zn that activated MAPK was sufficient to induce a subsequent increase in IL-8 protein expression in BEAS cells, suggesting that MAPK may mediate metal-induced expression of inflammatory proteins in human bronchial epithelial cells.