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Debra J. Taxman
Researcher at University of North Carolina at Chapel Hill
Publications - 40
Citations - 4624
Debra J. Taxman is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Inflammasome & Caspase 1. The author has an hindex of 29, co-authored 40 publications receiving 4241 citations. Previous affiliations of Debra J. Taxman include Pennsylvania State University.
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Journal ArticleDOI
The NLRP3 Inflammasome Mediates in vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA
Irving C. Allen,Margaret A. Scull,Chris B. Moore,Eda K. Holl,Erin McElvania-TeKippe,Debra J. Taxman,Elizabeth H. Guthrie,Raymond J. Pickles,Jenny P.-Y. Ting +8 more
TL;DR: Mechanistically, NLRP3 inflammasome activation by the influenza virus was dependent on lysosomal maturation and reactive oxygen species (ROS), and inhibition of ROS induction eliminated IL-1beta production in animals during influenza infection.
Journal ArticleDOI
NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways
Stephen B. Willingham,Irving C. Allen,Daniel T. Bergstralh,Willie June Brickey,Max Tze Han Huang,Debra J. Taxman,Joseph A. Duncan,Jenny P.-Y. Ting +7 more
TL;DR: Using a pulmonary infection model that reflects human infection, it is shown that K. pneumoniae infection of mice lacking Nlrp3 results in decreased lung inflammation and reduced survival relative to control, indicating the overall protective role of this gene.
Book ChapterDOI
Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown.
TL;DR: These studies demonstrate the practicality of including two shRNAs with different efficacies of knockdown to provide an additional level of control and to verify dose dependency of functional effects, and suggest suggestions for designing shRNA targets and controls.
Journal ArticleDOI
Microbial Pathogen-Induced Necrotic Cell Death Mediated by the Inflammasome Components CIAS1/Cryopyrin/NLRP3 and ASC
Stephen B. Willingham,Daniel T. Bergstralh,William T. O'Connor,Amy C. Morrison,Debra J. Taxman,Joseph A. Duncan,Shoshana Barnoy,Malabi M. Venkatesan,Richard A. Flavell,Mohanish Deshmukh,Hal M. Hoffman,Jenny P.-Y. Ting +11 more
TL;DR: Cryopyrin is identified as an important host regulator of programmed pathogen-induced necrosis in animals, a process the authors term pyronecrosis.
Journal ArticleDOI
The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy
Yu Lei,Haitao Wen,Yanbao Yu,Debra J. Taxman,Lu Zhang,Douglas G. Widman,Karen V. Swanson,Kwun Wah Wen,Blossom Damania,Christopher Brooks Moore,Patrick M. Giguère,David P. Siderovski,John Hiscott,Babak Razani,Clay F. Semenkovich,Xian Chen,Jenny P.-Y. Ting +16 more
TL;DR: This study establishes a link between an NLR protein and the viral-induced autophagic machinery via an intermediary partner, TUFM, which has similar functions as NLRX1 by inhibiting RLR-induced IFN-I but promoting autophagy.