H
Heather M. Scobie
Researcher at Salk Institute for Biological Studies
Publications - 32
Citations - 1712
Heather M. Scobie is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Medicine & Disease. The author has an hindex of 8, co-authored 11 publications receiving 1237 citations. Previous affiliations of Heather M. Scobie include University of Wisconsin-Madison.
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Journal ArticleDOI
Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
TL;DR: A soluble version of the CMG2 VWA/I domain inhibited intoxication of cells expressing endogenous toxin receptors when it was added to PA at a 3:1 ratio and identified a potent antitoxin that may prove useful for the treatment of anthrax.
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COVID-19 Incidence and Death Rates Among Unvaccinated and Fully Vaccinated Adults with and Without Booster Doses During Periods of Delta and Omicron Variant Emergence — 25 U.S. Jurisdictions, April 4–December 25, 2021
Amelia G Johnson,Avnika B. Amin,Akilah R. Ali,Brooke E. Hoots,Betsy L. Cadwell,Shivani Arora,Tigran Avoundjian,Abiola O. Awofeso,Jason Barnes,Nagla S. Bayoumi,Katherine Busen,Carolyn Chang,Michael J. Cima,Molly J. Crockett,Alicia Cronquist,Sherri L. Davidson,Elizabeth M. Davis,Janelle Delgadillo,Vajeera Dorabawila,Cherie Drenzek,Leah Eisenstein,H. Fast,A. M. van Gent,Julie Hand,Dina Hoefer,Corinne Holtzman,Amanda Jara,Amanda B. Jones,Ishrat Kamal-Ahmed,Sarah Kangas,Fnu Kanishka,Ramandeep Kaur,S. Khan,Justice Eleanor King,Sam E. Kirkendall,Anna Klioueva,Anna Kocharian,Frances Y Kwon,Jacqueline Logan,B. Casey Lyons,S. L. Lyons,Andrea L. May,Donald McCormick,Erica Mendoza,Lauren Milroy,Allison T. O'Donnell,Melissa G. Pike,Sargis Pogosjans,Amy Saupe,Jessica Sell,E. Smith,Daniel M. Sosin,Emma Suzanne Stanislawski,Molly Steele,Meagan Stephenson,A. M. Stout,Kyle Strand,Buddhi Tilakaratne,Kathryn Turner,Hailey Vest,Sydni Warner,Caleb Wiedeman,Allison Zaldivar,Benjamin J. Silk,Heather M. Scobie +64 more
TL;DR: The highest impact of booster doses against infection and death compared with full vaccination without booster doses was recorded among persons aged 50-64 and ≥65 years, and eligibility to stay up to date with COVID-19 vaccinations.
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Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: An anthrax toxin receptor
TL;DR: The structural data allow molecular interpretation of known CMG2 VWA domain mutations linked to the genetic disorders, juvenile hyaline fibromatosis, and infantile systemic hyalinosis and may facilitate understanding of toxin assembly/internalization and the development of new anthrax treatments.
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Receptor-specific requirements for anthrax toxin delivery into cells
G. Jonah A. Rainey,Darran J. Wigelsworth,Patricia L. Ryan,Heather M. Scobie,R. John Collier,John A. Young +5 more
TL;DR: It is suggested that toxin can form pores at different points in the endocytic pathway, depending on which receptor is used for entry, and that because PA binds to CMG2 with much higher affinity than it does to TEM8, a lower pH is needed to attenuateCMG2 binding to allow pore formation.
Journal ArticleDOI
Genomic Surveillance for SARS-CoV-2 Variants: Predominance of the Delta (B.1.617.2) and Omicron (B.1.1.529) Variants — United States, June 2021–January 2022
Anastasia S. Lambrou,Phillip Shirk,Molly Steele,Prabasaj Paul,Clinton R. Paden,Betsy L. Cadwell,Heather Reese,Yutaka Aoki,N. Hassell,Xiao-Yu Zheng,Sarah Elizabeth Talarico,Jessica Chen,M. Steven Oberste,Dhwani Batra,Laura K. McMullan,Alison Laufer Halpin,Summer E. Galloway,Duncan MacCannell,Rebecca Kondor,John R. Barnes,Adam MacNeil,Benjamin J. Silk,Vivien G. Dugan,Heather M. Scobie,David E. Wentworth +24 more
TL;DR: For example, the SARS-CoV-2 Delta (B.1.529 and BA sublineages) variant increased from 1% to >50% of circulating viral lineages during 8 weeks, from May 1-June 26, 2021 as mentioned in this paper .