Laura K. McMullan

TL;DR: These results show the first substantive post-exposure protection by a small-molecule antiviral compound against EBOV in nonhuman primates, and the broad-spectrum antiviral activity of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenavirus, and coronavirus suggests the potential for wider medical use.

TL;DR: A phlebovirus, which is novel in the Americas, is the cause of this clinical syndrome, and Koch's postulates have not been completely fulfilled.

TL;DR: Full genome analyses of LUJV showed it to be unique and branching off the ancestral node of the Old World arenaviruses, consistent with a potential distinctive receptor tropism.

TL;DR: The antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families are reported, providing evidence to support new indications for this compound against human viruses of significant public health concern.

TL;DR: Examination of the whole family suggests that members of the Filoviridae, including the recently described Lloviu virus, shared a most recent common ancestor approximately 10,000 years ago, which is valuable for understanding the evolution of filoviruses in the context of natural history.