Hedok Lee

TL;DR: It is proposed that this MRI approach may provide the basis for a wholly new strategy to evaluate Alzheimer's disease susceptibility and progression in the live human brain.

TL;DR: Experimental models show that perivascular spaces are important conduits for uptake of cerebrospinal fluid to flush interstitial fluid and clear metabolic waste; these processes seem to increase during sleep.

TL;DR: It is proposed that the most popular sleep posture (lateral) has evolved to optimize waste removal during sleep and that posture must be considered in diagnostic imaging procedures developed in the future to assess CSF-ISF transport in humans.

TL;DR: This review aims to provide an overview and discussion of the concept behind the glymphatic system, current evidence, and controversies, while specifically focusing on the consequences of aging and evidence of its existence in human brain.

TL;DR: BPD patients show greater amygdala activity and heightened activity of visual processing regions relative to findings for HC subjects in the processing of negative social emotional pictures compared with rest, and neural networks in emotion processing that are phylogeneticall older and more reflexive than those activated by HC subjects.