H
Humberto Mestre
Researcher at University of Rochester Medical Center
Publications - 48
Citations - 4194
Humberto Mestre is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Glymphatic system & Neuroprotection. The author has an hindex of 20, co-authored 46 publications receiving 2042 citations. Previous affiliations of Humberto Mestre include Universidad Anáhuac México Norte & University of Rochester.
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Journal ArticleDOI
The glymphatic pathway in neurological disorders
TL;DR: The observed reduction in CSF clearance was associated with increasing grey-matter concentrations of Aβ in the human brain, consistent with findings in mice showing that decreased glymphatic function leads to Aβ accumulation and the development of neurodegenerative diseases.
Journal ArticleDOI
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.
Humberto Mestre,Jeffrey Tithof,Ting Du,Ting Du,Wei Song,Weiguo Peng,Weiguo Peng,Amanda M. Sweeney,Genaro Olveda,John H. Thomas,Douglas H. Kelley +10 more
TL;DR: CSF flow speeds match the instantaneous speeds of the pulsing artery walls that form the inner boundaries of the PVSs, suggesting arterial wall motion is the principal driving mechanism, via a process known as perivascular pumping.
Journal ArticleDOI
Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.
Weiguo Peng,Thiyagarajan M. Achariyar,Baoman Li,Yonghong Liao,Humberto Mestre,Emi Hitomi,Sean Regan,Tristan Kasper,Sisi Peng,Fengfei Ding,Helene Benveniste,Rashid Deane +11 more
TL;DR: It is shown that CSF-derived Aβ40 co-localizes with existing endogenous vascular and parenchymal amyloid-β plaques, and thus, may contribute to the progression of both cerebral amyloids angiopathy andparenchylal Aβ accumulation.
Journal ArticleDOI
Perivascular spaces in the brain: anatomy, physiology and pathology
Joanna M. Wardlaw,Helene Benveniste,Berislav V. Zlokovic,Humberto Mestre,Hedok Lee,Fergus N. Doubal,Rosalind Brown,Joel Ramirez,Joel Ramirez,Bradley J. MacIntosh,Bradley J. MacIntosh,Allen Tannenbaum,Lucia Ballerini,Ravi L. Rungta,Davide Boido,Melanie D. Sweeney,Axel Montagne,Serge Charpak,Anne Joutel,Kenneth Smith,Sandra E. Black,Sandra E. Black +21 more
TL;DR: Experimental models show that perivascular spaces are important conduits for uptake of cerebrospinal fluid to flush interstitial fluid and clear metabolic waste; these processes seem to increase during sleep.
Journal ArticleDOI
Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Humberto Mestre,Lauren M. Hablitz,Anna L.R. Xavier,Weixi Feng,Wenyan Zou,Tinglin Pu,Hiromu Monai,Giridhar Murlidharan,Ruth M. Castellanos Rivera,Matthew J. Simon,Martin M. Pike,Virginia Plá,Ting Du,Benjamin T. Kress,Xiaowen Wang,Benjamin A. Plog,Alexander S. Thrane,Alexander S. Thrane,Iben Lundgaard,Iben Lundgaard,Yoichiro Abe,Masato Yasui,John H. Thomas,Ming Xiao,Hajime Hirase,Aravind Asokan,Aravind Asokan,Jeffrey J. Iliff +27 more
TL;DR: It is concur that CSF influx is higher in wild-type mice than in four different Aqp4 KO lines and in one line that lacks perivascular AQP4 (Snta1 KO), and it is reported that intrastriatal injections suppress glymphatic function.