S
Simon Sanggaard
Researcher at Yale University
Publications - 11
Citations - 1129
Simon Sanggaard is an academic researcher from Yale University. The author has contributed to research in topics: Glymphatic system & Cisterna magna. The author has an hindex of 8, co-authored 10 publications receiving 710 citations. Previous affiliations of Simon Sanggaard include University of Rochester Medical Center & University of Copenhagen.
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Journal ArticleDOI
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism
Iben Lundgaard,Baoman Li,Lulu Xie,Hongyi Kang,Simon Sanggaard,John Douglas R Haswell,Wei Sun,Siri Goldman,Solomiya Blekot,Michael L. Nielsen,Takahiro Takano,Rashid Deane +11 more
TL;DR: It is shown, using 2-photon imaging of a near-infrared 2-deoxyglucose analogue (2DG-IR), that glucose is taken up preferentially by neurons in awake behaving mice, and the neuron is identified as the principal locus of glucose uptake as visualized by functional brain imaging.
Journal ArticleDOI
The Glymphatic System and Waste Clearance with Brain Aging: A Review
TL;DR: This review aims to provide an overview and discussion of the concept behind the glymphatic system, current evidence, and controversies, while specifically focusing on the consequences of aging and evidence of its existence in human brain.
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White matter astrocytes in health and disease
TL;DR: It is suggested that specific manipulation of astrocytes could help prevent myelin pathologies and successfully restore myelin sheaths after demyelination.
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Impaired Glymphatic Transport in Spontaneously Hypertensive Rats
Kristian Nygaard Mortensen,Simon Sanggaard,Simon Sanggaard,Humberto Mestre,Hedok Lee,Serhii Kostrikov,Anna L.R. Xavier,Albert Gjedde,Albert Gjedde,Helene Benveniste +9 more
TL;DR: The study demonstrates the suppression of glymphatic clearance in SHR rats and thus offers new insight into the coexistence of hypertension and concomitant vascular pathologies in Alzheimer's disease, as well as providing a new perspective on the importance for brain metabolite and fluid homeostasis of maintaining healthy blood vessels.
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Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.
Sunil Koundal,Rena Elkin,Saad Nadeem,Yuechuan Xue,Stefan Constantinou,Simon Sanggaard,Xiaodan Liu,Brittany Monte,Feng Xu,William E. Van Nostrand,Hedok Lee,Joanna M. Wardlaw,Helene Benveniste,Allen Tannenbaum +13 more
TL;DR: A regularized version of the optimal mass transport (rOMT) problem, wherein the advection/diffusion equation is the only a priori assumption required, provides novel insights in the local dynamics of glymphatic system transport that may have implications for neurodegenerative diseases.