R
Rashid Deane
Researcher at University of Rochester
Publications - 84
Citations - 23923
Rashid Deane is an academic researcher from University of Rochester. The author has contributed to research in topics: Blood–brain barrier & Glymphatic system. The author has an hindex of 50, co-authored 81 publications receiving 19439 citations. Previous affiliations of Rashid Deane include State University of New York System & University of Rochester Medical Center.
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Journal ArticleDOI
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Jeffrey J. Iliff,Minghuan Wang,Minghuan Wang,Yonghong Liao,Benjamin A. Plogg,Weiguo Peng,Georg Andreas Gundersen,Helene Benveniste,G. Edward Vates,Rashid Deane,Steven A. Goldman,Erlend A. Nagelhus +11 more
TL;DR: An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.
Journal ArticleDOI
Sleep Drives Metabolite Clearance From the Adult Brain
Lulu Xie,Hongyi Kang,Qiwu Xu,Michael Chen,Yonghong Liao,Meenakshisundaram Thiyagarajan,John O’Donnell,Daniel J. Christensen,Charles Nicholson,Jeffrey J. Iliff,Takahiro Takano,Rashid Deane +11 more
TL;DR: It is reported that sleep has a critical function in ensuring metabolic homeostasis and convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep, suggesting the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.
Journal ArticleDOI
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Rashid Deane,Shi Du Yan,Ram Kumar Submamaryan,Barbara LaRue,Suzana Jovanovic,Elizabeth Hogg,Deborah Welch,Lawrence Manness,Chang Lin,Jin Yu,Hong Zhu,Jorge Ghiso,Blas Frangione,Alan Stern,Ann Marie Schmidt,Don L Armstrong,Bernd Arnold,Birgit Liliensiek,Peter P. Nawroth,Florence M. Hofman,Mark S. Kindy,David M. Stern,David M. Stern,Berislav V. Zlokovic +23 more
TL;DR: These findings suggest that vascular RAGE is a target for inhibiting pathogenic consequences of Aβ-vascular interactions, including development of cerebral amyloidosis.
Journal ArticleDOI
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.
Robert D. Bell,Ethan A. Winkler,Abhay P. Sagare,Itender Singh,Barb LaRue,Rashid Deane,Berislav V. Zlokovic +6 more
TL;DR: It is shown that age-dependent vascular damage in pericyte-deficient mice precedes neuronal degenerative changes, learning and memory impairment, and the neuroinflammatory response, and pericytes control key neurovascular functions that are necessary for proper neuronal structure and function.
Journal ArticleDOI
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
Robert D. Bell,Ethan A. Winkler,Itender Singh,Abhay P. Sagare,Rashid Deane,Zhenhua Wu,David M. Holtzman,Christer Betsholtz,Annika Armulik,Annika Armulik,Jan Sallstrom,Bradford C. Berk,Berislav V. Zlokovic,Berislav V. Zlokovic +13 more
TL;DR: It is shown that the vascular defects in Apoe-deficient and APOE4-expressing mice precede neuronal dysfunction and can initiate neurodegenerative changes, which suggest that CypA is a key target for treating APoe4-mediated neurovascular injury and the resulting neuronal Dysfunction and degeneration.