H
Hee-Seung Lee
Researcher at KAIST
Publications - 97
Citations - 3236
Hee-Seung Lee is an academic researcher from KAIST. The author has contributed to research in topics: Foldamer & Catalysis. The author has an hindex of 28, co-authored 92 publications receiving 2909 citations. Previous affiliations of Hee-Seung Lee include Chungnam National University & University of Wisconsin-Madison.
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Non-haemolytic β-amino-acid oligomers
TL;DR: In this article, a β-amino acid oligomer (β-peptide) was developed to mimic natural antibiotics and tested it for antimicrobial activity against four bacterial species including two pathogens that are resistant to common antibiotics.
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PIL5, a Phytochrome-Interacting bHLH Protein, Regulates Gibberellin Responsiveness by Binding Directly to the GAI and RGA Promoters in Arabidopsis Seeds
Eunkyoo Oh,Shinjiro Yamaguchi,Jianhong Hu,Jikumaru Yusuke,Byunghyuck Jung,Inyup Paik,Hee-Seung Lee,Tai-ping Sun,Yuji Kamiya,Giltsu Choi +9 more
TL;DR: Together, the results show that light signals perceived by phytochromes cause a reduction in the PIL5 protein level, which in turn regulates the transcription of two DELLA genes directly and that of GA and ABA metabolic genes indirectly.
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Chimeric (α/β + α)-Peptide Ligands for the BH3-Recognition Cleft of Bcl-xL: Critical Role of the Molecular Scaffold in Protein Surface Recognition
Jack D. Sadowsky,Margaret A. Schmitt,Hee-Seung Lee,Naoki Umezawa,Shaomeng Wang,York Tomita,Samuel H. Gellman +6 more
TL;DR: The results suggest that combining different types of foldamer backbones will be an effective and general strategy for creating high-affinity and specific ligands for protein surface sites.
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A single-molecule dissection of ligand binding to a protein with intrinsic dynamics
TL;DR: Kinetic analysis provided direct evidence that MBP recognizes a ligand through an 'induced-fit' mechanism, not through the generally proposed selection mechanism for proteins with conformational dynamics such as MBP, indicating that the mere presence of intrinsic dynamics is insufficient for a 'selection' mechanism.
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Circular dichroism study of chiral biomolecules conjugated with silver nanoparticles
TL;DR: In this article, the authors investigated the effect of conjugation of thiol group-containing biomolecules, such as cysteine, glutathione and penicillamine, with silver nanoparticles.