Heidi M. Blank

TL;DR: Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.

TL;DR: It is shown that Rad52-GFP foci form during S phase, consistent with the observation that DNA replication initiation and elongation are impaired in some aneuploid yeast strains, and indicates that by causing low levels of DNA damage, whole-chromosome aneuPLoidies lead to DNA breaks that persist into mitosis.

TL;DR: In this paper, the effects of aneuploidy on genomic stability were examined in yeast strains that carry extra copies of single chromosomes and found that all the strains exhibited one or more forms of genomic instability, including increased chromosome loss and mitotic recombination.

TL;DR: In this article , an RNA-centric proximity labeling technology was implemented at different points in the cell cycle in highly synchronous yeast cultures to identify proteins that bind the FAS1 transcript in a cell cycle-dependent manner.

TL;DR: In this paper , the first isotope tracing analysis in growing budding yeast cells was performed, showing that the synthesis of leucine, a branched-chain amino acid (BCAA), increased through the G1 phase of the cell cycle, peaking later during DNA replication.