Jason M. Sheltzer

TL;DR: Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.

TL;DR: It is suggested that stringent genetic validation of the mechanism of action of cancer drugs in the preclinical setting may decrease the number of therapies tested in human patients that fail to provide any clinical benefit.

TL;DR: It is shown that cigarette smoke causes a dose-dependent upregulation of Angiotensin Converting Enzyme 2 (ACE2), the SARS-CoV-2 receptor, in rodent and human lungs, and this work identifies ACE2 as an interferon-stimulated gene in lung cells, suggesting that Sars-Cov-2 infections could create positive-feedback loops that increase ACE2 levels and facilitate viral dissemination.

TL;DR: It is shown that high-achieving faculty members who are male train 10–40% fewer women in their laboratories relative to the number of women trained by other investigators, which may be one cause of the leaky pipeline in biomedical research.

TL;DR: It is demonstrated that aneuploidies of different chromosomes and in different organisms impact similar cellular pathways and cause a stereotypical antiproliferative response that must be overcome before transformation.