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Sarah J. Pfau
Researcher at Massachusetts Institute of Technology
Publications - 7
Citations - 749
Sarah J. Pfau is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Aneuploidy & Carcinogenesis. The author has an hindex of 6, co-authored 7 publications receiving 680 citations.
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Aneuploidy Drives Genomic Instability in Yeast
Jason M. Sheltzer,Heidi M. Blank,Sarah J. Pfau,Yoshie Tange,Benson M. George,Timothy J. Humpton,Ilana L. Brito,Yasushi Hiraoka,Yasushi Hiraoka,Osami Niwa,Angelika Amon +10 more
TL;DR: Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.
Journal ArticleDOI
Chromosomal instability and aneuploidy in cancer: from yeast to man.
Sarah J. Pfau,Angelika Amon +1 more
TL;DR: The effects of aneuploidy and chromosomal instability in cells and model systems of cancer are reviewed, a model that could explain these complex findings are proposed and how the aneuPLoid condition could be exploited in cancer therapy is discussed.
Journal ArticleDOI
Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo
TL;DR: It is found that aneuploid hematopoietic stem cells (HSCs) exhibit decreased fitness, which indicates that, in vivo, mechanisms exist to select against aneuPLoid cells.
Journal ArticleDOI
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis
Yun-Chi Tang,Hui Yuwen,Kaiying Wang,Peter M. Bruno,Kevin Bullock,Amy Deik,Stefano Santaguida,Marianna Trakala,Sarah J. Pfau,Na Zhong,Tao Huang,Lan Wang,Clary B. Clish,Michael T. Hemann,Angelika Amon +14 more
TL;DR: The results offer pharmacologic evidence that the aneuploid state in cancer cells can be targeted selectively for therapeutic purposes, or for reducing the toxicity of taxane-based drug regimens.
Aneuploidy Drives Genomic Instability in Yeast
Jason M. Sheltzer,Heidi M. Blank,Sarah J. Pfau,Yoshie Tange,Benson M. George,Timothy J. Humpton,Ilana L. Brito,Yasushi Hiraoka,Yasushi Hiraoka,Osami Niwa,Angelika Amon +10 more
TL;DR: In this paper, the effects of aneuploidy on genomic stability were examined in yeast strains that carry extra copies of single chromosomes and found that all the strains exhibited one or more forms of genomic instability, including increased chromosome loss and mitotic recombination.