O
Osami Niwa
Researcher at Kyoto University
Publications - 35
Citations - 3083
Osami Niwa is an academic researcher from Kyoto University. The author has contributed to research in topics: Schizosaccharomyces pombe & Centromere. The author has an hindex of 25, co-authored 35 publications receiving 2992 citations. Previous affiliations of Osami Niwa include Rockefeller University.
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Journal ArticleDOI
Aneuploidy Drives Genomic Instability in Yeast
Jason M. Sheltzer,Heidi M. Blank,Sarah J. Pfau,Yoshie Tange,Benson M. George,Timothy J. Humpton,Ilana L. Brito,Yasushi Hiraoka,Yasushi Hiraoka,Osami Niwa,Angelika Amon +10 more
TL;DR: Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.
Journal ArticleDOI
A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere.
Kohta Takahashi,Shin Murakami,Yuji Chikashige,Hironori Funabiki,Osami Niwa,Mitsuhiro Yanagida +5 more
TL;DR: The behavior of truncated minichromosomes suggested that the central region is essential, but not sufficient, to confer transmission stability, whereas the outer regions may interact with each other to form the higher-order complex structure.
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Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis.
Hiroyuki Ohkura,Yuichiro Adachi,Noriyuki Kinoshita,Osami Niwa,Takashi Toda,Mitsuhiro Yanagida +5 more
TL;DR: It is found that all the dis mutants isolated are supersensitive to caffeine at permissive temperature and suggested that the dis genes are required for the sister chromatid separation at the time of mitosis and that caffeine might affect the dis gene expression.
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Composite motifs and repeat symmetry in S. pombe centromeres: Direct analysis by integration of Notl restriction sites
Yuji Chikashige,Noriyuki Kinoshita,Yukinobu Nakaseko,Tomohiro Matsumoto,Shin Murakami,Osami Niwa,Mitsuhiro Yanagida +6 more
TL;DR: A method that enables us to characterize directly centromere DNAs in S. pombe centromeres appears to play a role in chromosome stability and segregation and the mutual directions of dg and dh inside a motif may not be essential for function.
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Chromosome walking shows a highly homologous repetitive sequence present in all the centromere regions of fission yeast.
TL;DR: The structures in or surrounding the centromeres of S. pombe appear to be much more complex than those of the budding yeast Saccharomyces cerevisiae, which has three chromosomes.