H
Heike Baron
Researcher at Humboldt University of Berlin
Publications - 10
Citations - 425
Heike Baron is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Familial hypercholesterolemia & Apolipoprotein B. The author has an hindex of 8, co-authored 10 publications receiving 420 citations. Previous affiliations of Heike Baron include Bernhard Nocht Institute for Tropical Medicine & Applied Biosystems.
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Journal ArticleDOI
A Cholesterol-Lowering Gene Maps to Chromosome 13q
Hans Knoblauch,Bertram Müller-Myhsok,Andreas Busjahn,Liat Ben Avi,Sylvia Bähring,Heike Baron,Simon Heath,Regina Uhlmann,Hans-Dieter Faulhaber,Shoshi Shpitzen,Atakan Aydin,Ayeleth Reshef,Magda Rosenthal,Osnat Eliav,Astrid Mühl,Adam Lowe,Danny Schurr,Dror Harats,Evi Jeschke,Yechiel Friedlander,Herbert Schuster,Friedrich C. Luft,Eran Leitersdorf +22 more
TL;DR: A cholesterol-lowering gene has been postulated from familial hypercholesterolemia (FH) families having heterozygous persons with normal LDL levels and homozygous individuals with LDL levels similar to those in persons withheterozygous FH, and strong evidence for linkage at this locus with LDL is found.
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LDLR Database (second edition): New additions to the database and the software, and results of the first molecular analysis
Mathilde Varret,Jean-Pierre Rabès,Rochelle Thiart,Maritha J. Kotze,Heike Baron,Ana Cenarro,Olivier S. Descamps,M. Ebhardt,Jean-Claude Hondelijn,Gert M. Kostner,Yasuko Miyake,Miguel Pocovi,Hartmut H.-J. Schmidt,Helena Schmidt,Herbert Schuster,Manfred Stuhrmann,Taku Yamamura,Claudine Junien,Christophe Béroud,Catherine Boileau +19 more
TL;DR: The second version of the LDLR database contains 140 new entries and the software has been modified to accommodate four new routines, and the analysis of the updated data gives the following informations.
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Oligonucleotide ligation assay (OLA) for the diagnosis of familial hypercholesterolemia
TL;DR: An Oligonucleotide ligation assay (OLA) is developed that enables to screen for high-risk individuals by testing for 19 common mutations in the LDL receptor and the apolipoprotein B genes using an automated genotyping-based two-step protocol and uses oligomeric pentaethyleneoxide mobility modifiers.
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Support for linkage of familial combined hyperlipidemia to chromosome 1q21–q23 in Chinese and German families
Weidong Pei,Heike Baron,Bertram Müller-Myhsok,Hans Knoblauch,Said Ali Al-Yahyaee,Rutai Hui,Xi-gui Wu,Li sheng Liu,Andreas Busjahn,Friedrich C. Luft,Herbert Schuster +10 more
TL;DR: It is suggested that RXR is an attractive candidate for involvement in FCHL since D1S194 is adjacent to the gene for the RXR, which was found to be linked to triglyceride levels in an earlier twin study from the authors' laboratory.
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A new mutation in the elastin gene causing supravalvular aortic stenosis.
Thomas Boeckel,Astrid Dierks,Athanasios Vergopoulos,Sylvia Bähring,Hans Knoblauch,Bertram Müller-Myhsok,Heike Baron,Atakan Aydin,Georg Bein,Friedrich C. Luft,Herbert Schuster +10 more
TL;DR: A large supravalvular aortic stenosis kindred, with a point mutation in exon 18 and a stop codon in ex on 22 of the elastin gene, is described.