Heike Goehler

TL;DR: A large, highly connected network of interacting pairs of human proteins was identified, characterizing ANP32A and CRMP1 as modulators of Wnt signaling and two novel Axin-1 interactions were validated experimentally.

TL;DR: A strategy combining library and matrix yeast two-hybrid screens to generate a highly connected PPI network for Huntington's disease (HD) revealed 165 new potential interactions and facilitated the discovery of GIT1, a G protein-coupled receptor kinase-interacting protein, which enhances huntingtin aggregation by recruitment of the protein into membranous vesicles.

TL;DR: Large perinuclear vesicle-like structures containing HIP1, huntingtin, clathrin and endocytosed transferrin were observed, indicating that HIP1 is an endocytic protein, the structural integrity of which is crucial for maintenance of normal vesicles size in vivo.

TL;DR: The verification of the interaction between htt and GASP2 (G protein-coupled receptor associated sorting protein 2), a protein involved in membrane receptor degradation, is described, suggesting that htt might influence receptor trafficking via the interaction with GASp2.

TL;DR: Investigating whether aggregation-promoting polyglutamine (polyQ) tracts can stimulate the de novo formation of ordered Sup35 protein aggregates in the absence of Q/N-rich yeast prions found that Sup35 fusions with pathogenic polyQ tracts efficiently form seeding-competentprotein aggregates.