H
Heiko E. von der Leyen
Researcher at Stanford University
Publications - 13
Citations - 1070
Heiko E. von der Leyen is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Vascular smooth muscle. The author has an hindex of 9, co-authored 12 publications receiving 1059 citations. Previous affiliations of Heiko E. von der Leyen include Brigham and Women's Hospital.
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Journal ArticleDOI
Expression of Inducible Nitric Oxide Synthase in Human Heart Failure
Guy A. Haywood,Philip S. Tsao,Heiko E. von der Leyen,Michael J. Mann,Philip J. Keeling,Pedro T. Trindade,Neil P. Lewis,Christopher D. Byrne,Peter Rickenbacher,Nanette H. Bishopric,John P. Cooke,William J. McKenna,Michael B. Fowler +12 more
TL;DR: iNOS expression occurs in failing human cardiac myocytes and may be involved in the pathophysiology of DCM, IHD, and VHD.
Journal ArticleDOI
Induction of Nitric Oxide Synthase in the Human Cardiac Allograft Is Associated With Contractile Dysfunction of the Left Ventricle
Neil P. Lewis,Neil P. Lewis,Philip S. Tsao,Peter Rickenbacher,Chun Xue,Roger A. Johns,Guy A. Haywood,Heiko E. von der Leyen,Pedro T. Trindade,John P. Cooke,Sharon A. Hunt,M. E. Billingham,Hannah A. Valantine,Michael B. Fowler +13 more
TL;DR: The hypothesis that induction of iNOS may occur and be associated with cardiac allograft contractile dysfunction in humans is tested and data support a relation between inducible nitric oxide synthase mRNA expression and contractiles dysfunction in the human cardiacAllograft.
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Cell Cycle Protein Expression in Vascular Smooth Muscle Cells In Vitro and In Vivo Is Regulated Through Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin
Ruediger C. Braun-Dullaeus,Michael J. Mann,Ulrike Seay,Lunan Zhang,Heiko E. von der Leyen,Randall E. Morris,Victor J. Dzau +6 more
TL;DR: The data suggest that cell cycle progression in vascular cells in vitro and in vivo depends on the integrity of the PI 3-kinase signaling pathway in allowing posttranscriptional accumulation of cell cycle proteins.
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A novel role for the cyclin-dependent kinase inhibitor p27Kip1 in angiotensin II–stimulated vascular smooth muscle cell hypertrophy
Ruediger C. Braun-Dullaeus,Michael J. Mann,Almut Ziegler,Heiko E. von der Leyen,Victor J. Dzau +4 more
TL;DR: Angiotensin II stimulation of quiescent cells in which p27(Kip1) levels are high results in hypertrophy but promotes hyperplasia when levels of p 27(KIP1) are low, as in the presence of other growth factors.
Journal ArticleDOI
Cell Cycle–Dependent Regulation of Smooth Muscle Cell Activation
Ruediger C. Braun-Dullaeus,Michael J. Mann,Daniel Sedding,Steven W. Sherwood,Heiko E. von der Leyen,Victor J. Dzau +5 more
TL;DR: Early cell cycle phases may represent states in which the responses to a variety of stimuli that influence cell fate can be modulated, and these observations may have novel implications for the prevention and/or therapy of vascular proliferative, neoplastic, and inflammatory diseases.