H
Heinrich V. Malling
Researcher at National Institutes of Health
Publications - 50
Citations - 1169
Heinrich V. Malling is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mutant & Neurospora crassa. The author has an hindex of 13, co-authored 50 publications receiving 1141 citations. Previous affiliations of Heinrich V. Malling include Meredith College.
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Journal ArticleDOI
An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals: A report of the U.S. environmental protection agency Gene-Tox program
Andrew J. Wyrobek,Laurie Gordon,James G. Burkhart,Mary W. Francis,Robert W. Kapp,Gideon Letz,Heinrich V. Malling,John C. Topham,M.Donald Whorton +8 more
TL;DR: The mouse sperm morphology test has potential use for identifying chemicals that induce spermatogenic dysfunction and perhaps heritable mutations, and is found to be highly sensitive to germ-cell mutagens.
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An evaluation of human sperm as indicators of chemically induced alterations of spermatogenic function. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
Andrew J. Wyrobek,Laurie Gordon,James G. Burkhart,Mary W. Francis,Robert W. Kapp,Gideon Letz,Heinrich V. Malling,John C. Topham,M.Donald Whorton +8 more
TL;DR: There is strong evidence that human sperm tests can be used to identify chemicals that affect sperm production, but because of the limited understanding of underlying mechanisms, the extent to which they can detect mutagens, carcinogens or agents that affect fertility remains uncertain.
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Do Airborne Particles Induce Heritable Mutations
TL;DR: The germline mutation rate was reduced by about 50% if the mice were exposed to air cleansed of particulate matter by passage through a HEPA filter.
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Genetic effects of crocidolite asbestos in Chinese hamster lung cells
TL;DR: Chinese hamster lung cells cultured in the presence of crocidolite asbestos displayed inhibition of cell growth and Phagocytosed asbestos appeared to be a weak mutagen in its ability to induce gene mutation at the hypoxanthine-guanine phosphoribosyl transferase locus.
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Assessing human germ-cell mutagenesis in the Postgenome Era: a celebration of the legacy of William Lawson (Bill) Russell.
Andrew J. Wyrobek,John J. Mulvihill,John S. Wassom,Heinrich V. Malling,Michael D. Shelby,Susan E. Lewis,Kristine L. Witt,R. Julian Preston,Sally D. Perreault,James W. Allen,David M. DeMarini,Richard P. Woychik,Jack B. Bishop +12 more
TL;DR: The purpose of the workshop was to assess the applicability of an emerging repertoire of genomic technologies to studies of human germ‐cell mutagenesis, and agreed on the need for a full‐scale assault to address key fundamental questions in human germ-cell environmental Mutagenesis.