H
Helen Todd
Publications - 11
Citations - 91
Helen Todd is an academic researcher. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 5, co-authored 11 publications receiving 76 citations.
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Journal ArticleDOI
Duration of protective immunity and antibody responses in cattle immunised against alcelaphine herpesvirus-1-induced malignant catarrhal fever.
George C. Russell,Julio Benavides,Dawn M. Grant,Helen Todd,David Deane,Ann Percival,Jackie Thomson,Maira Connelly,David M. Haig +8 more
TL;DR: The results presented here show that the attenuated AlHV-1 vaccine in a licensed adjuvant protected cattle from fatal intranasal challenge with pathogenic AlH V-1 at three or six months, and suggests that the magnitude of the initial response may correlate with long-term protection.
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The effect of the TLR9 ligand CpG-oligodeoxynucleotide on the protective immune response to alcelaphine herpesvirus-1-mediated malignant catarrhal fever in cattle
Nevi Parameswaran,George C. Russell,Kathryn Bartley,Dawn M. Grant,David Deane,Helen Todd,Mark P. Dagleish,David M. Haig +7 more
TL;DR: The results suggested that nAbs at the oro-nasal-pharyngeal region are important in protection against AlHV-1 MCF, and CpG ODN alone as adjuvant did not support the generation of virus-neutralising antibodies.
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Structural and functional diversity arising from intra- and inter-haplotype combinations of duplicated DQA and B loci within the ovine MHC.
TL;DR: Evidence is provided that DQA 2-like and B2-like genes form an evolutionary conserved pair which generates structurally distinct class II molecules that are likely to present a distinct range of peptides to CD4+ T cells.
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A novel spliced gene in alcelaphine herpesvirus 1 encodes a glycoprotein which is secreted in vitro.
George C. Russell,Helen Todd,David Deane,Ann Percival,Mark P. Dagleish,David M. Haig,James P. Stewart +6 more
TL;DR: A novel spliced gene in two related macaviruses that is expressed in MCF lesions in infected cattle is identified and future work will determine its importance for the pathogenesis of disease.
Journal ArticleDOI
Host gene expression changes in cattle infected with Alcelaphine herpesvirus 1.
George C. Russell,Julio Benavides,Dawn M. Grant,Helen Todd,Jackie Thomson,Vipul Puri,Mintu Nath,David M. Haig +7 more
TL;DR: Microarray expression study of AlHV-1 infection in the natural (bovine) host consistent with chronic inflammatory pathology involving IFNγ shows 35 genes had significantly altered expression in MCF-affected lymph node and kidney.