Helena Barrasa

TL;DR: This early experience with SARS-CoV-2 in Spain suggests that a strategy of right oxygenation avoiding non-invasive mechanical ventilation was life-saving.

TL;DR: Augmented renal clearance is a prevalent condition in critically ill patients, especially in young people, with urinary CrCl being the best diagnostic method because mathematical estimates tend to underestimate CrCl.

TL;DR: ARC increases linezolid CL and leads to a high risk of underexposure with the standard dose, but an infusion rate of 75 mg/h should be considered to ensure C ≥‬2 2‬mg/mL, while continuous infusion increases the PTA.

TL;DR: The PK/PD analysis confirmed that 280- and 420-mg/d dosages would not be enough to achieve high probabilities of target attainment for MIC values ≥ 1 mg/L in patients with Clcr ≥ 60 mL/min or in subjects with lower Clcrs but receiving CRRT.

TL;DR: The standard dose (600mg q12h) ensures a moderately high probability of treatment success in anuric patients when the infection is due to microorganisms with MIC≤2mg/L; in patients with residual renal function, the standard dose is insufficient, but 900mg q8h provide higher probability of Treatment success without compromising the safety.