María Ángeles Solinís

TL;DR: The understanding of the nanostructured lipid carriers (NLC)-based formulations has improved with continuing research recently, and the result has seen an increase in the use of these in the clinical setting.

TL;DR: By modifying critical physicochemical parameters of the NLC formulation, this work was able to overcome the P-gp drug efflux and alter the transcytosis mechanism of the nanoparticles, which support the use of NLCs approaches for oral delivery of poorly water-soluble P- gp substrates.

TL;DR: Augmented renal clearance is a prevalent condition in critically ill patients, especially in young people, with urinary CrCl being the best diagnostic method because mathematical estimates tend to underestimate CrCl.

TL;DR: LyoSLNs showed less DNA condensation capacity, whereas in Lyo(SLN-DNA) the plasmid became strongly bound, hampering the transfection, and the storage of lyophilized lipoplexes stabilized with the disaccharide trehalose did not affect cell viability.

TL;DR: This manuscript includes a revision of the strategies employed to enhance in vitro transcribed mRNA functionality and efficacy, including the optimization of its stability and translational efficiency, as well as the regulation of its immunostimulatory properties.