Showing papers in "International Journal of Antimicrobial Agents in 2018"

TL;DR: A global effort must be made to cease antimicrobial overuse in aquaculture and encourage stakeholders to adopt other disease-prevention measures.

TL;DR: This review summarises industrially interesting antimicrobial bioactivities as well as their mechanisms of action for three main types of plant nutraceuticals, namely terpenoids, polyphenols and thiols, which are important constituents of plant essential oils with a broad range of antimicrobial effects.

TL;DR: Staphylococcus aureus-specific bacteriophage Sb-1 can degrade the MRSA polysaccharide matrix and target persister cells and is therefore suitable for treatment of biofilm-associated infections.

TL;DR: In this paper, the availability of antimicrobial agents without a doctor's prescription in developing countries was explored and factors that contribute to inappropriate antimicrobial supply in community pharmacies in these countries were investigated.

TL;DR: Limiting antimicrobial use in food animals reduces antimicrobial resistance inFood animals, and probably reduces antimacterial resistance in humans, although the magnitude of the effect could not be quantified.

TL;DR: The results show that the pig industry is an important reservoir of colistin-resistant E. coli, carriers of other additional risk genes, such as blaESBL, which might be spreading a cocktail of multiple resistances, posing a worrisome threat to human health.

TL;DR: Three distinct classes of antimicrobial peptides that include the clinically used antibiotic colistin, the natural AMP LL37, the engineered cationic-AMP WLBU2, and four commonly used antibiotics with different bactericidal mechanisms are compared for biofilm prevention properties.

TL;DR: Meropenem/vaborbactam was active against contemporary CRE and wild-type Enterobacteriaceae collected worldwide and this combination demonstrated enhanced activity compared with meropenem and most comparator agents against CRE and KPC-producers.

TL;DR: Loss or deficiency of OMPs, coupled with ESBL and/or AmpC production, plays an important role in conferring carbapenem resistance in K. pneumoniae.

TL;DR: Eravacycline was the most potent antibiotic of those tested against A. baumannii, including isolates that were resistant to sulbactam, imipenem/meropenem, levofloxacin and amikacin/tobramycin.

TL;DR: Findings show for the first time the feasibility of utilizing the antimicrobial property of copper by adding nanosized fillers to other materials in a hospital environment.

TL;DR: It is shown that OPAT is safe, clinically efficacious and acceptable for treating a wide range of infections with high levels of patient satisfaction and substantial cost savings.

TL;DR: Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions and suffers from a selective reporting bias towards community-associated methicillin-resistant S. a Aureus.

TL;DR: Mcr-1 was widespread in E. coli with low fitness cost from various origins, indicating an urgent need to take measures for decreasing dissemination.

TL;DR: Beyond the overall high colistin resistance rate in CRE, the emergence of a highly resistant clone of K. pneumoniae ST14 in all Dubai hospitals investigated is a serious problem requiring immediate attention.

TL;DR: S sulfamethoxazole represents a promising co-drug that can restore the efficacy of certain azole antifungal drugs against some azole-resistant isolates of C. auris, and is dependent on the underlying mechanism of azole resistance.

TL;DR: Findings indicate differential responses of different Candida species with respect to antiseptic challenge against biofilms, with C. auris appearing to be more resilient as a complex community.

TL;DR: Inhaled colistin monotherapy may deserve further consideration as a mode forcolistin administration for the treatment of respiratory tract infections caused by MDR A. baumannii and P. aeruginosa.

TL;DR: Non-Aspergillus IMIs were detected in patients with various underlying diseases and were associated with high mortality rates, which was significantly lower in those who received antifungal combination therapy.

TL;DR: The emergence and dissemination of blaNDM variants in hospital sewage water is a matter of concern, creating an endemic scenario leading to the level of an outbreak.

TL;DR: This study shows that 16S RMTases occur in the UK and Ireland and carbapenemases are particularly prevalent in 16SRMTase-producing Enterobacteriaceae, which poses a risk to the treatment of multidrug-resistant Gram-negative infections in the clinical setting.

TL;DR: The first detection of NDM-5-producing Escherichia coli sequence type 167 (ST167) isolates from two patients with urinary tract infection, including one with colonisation admitted to the same hospital 2 months apart in 2017 is reported.

TL;DR: The genome sequences of two multidrug-resistant E. coli carrying ColV-like plasmids, irrespective of their phylogroup or ST, may pose a potential threat to human health, particularly to the elderly and immunocompromised, according to a combination of Illumina and Single Molecule, Real-Time (SMRT) sequencing.

TL;DR: FQs are associated with more CNS- and GI-related AEs compared with other types of antimicrobial, and this information is relevant to support decision making in relation to antimicrobial prescribing.

TL;DR: This study aimed to characterise a novel multidrug resistance megaplasmid carrying qnrVC6 and blaIMP-45 from Pseudomonas aeruginosa strain Guangzhou-Pae617 isolated from a patient hospitalised in Guangzhou, China, in 2012.

TL;DR: In the current context of ESBL-E dissemination and increasing opportunities for carbapenem-sparing initiatives, large, comparative, high-quality studies based on new-generation sequencing tools are more than ever warranted to better define the positioning of alternative β-lactams in antimicrobial stewardship programmes.

TL;DR: Multiple optrA variants located on distinct plasmids and mobile genetic elements with the potential for conjugative transfer are supposedly causative for the emergence of OptrA-positive enterococci, suggesting rapid dissemination of the resistance determinant under selective pressure imposed by extensive use of last-resort antibiotics in clinical settings could be expected.

TL;DR: Adjunctive intravenous azithromycin therapy was effective in patients with moderate or severe ARDS, and further prospective randomized controlled trials are needed to confirm this result.

TL;DR: It is characterised a novel Y. pestis strain (IP2180H) that exhibited resistance to doxycycline that was isolated from a rat in Antananarivo (Madagascar) in 1998 and carried a conjugative plasmid homologous to pB71 from Salmonella enterica.