Helge Walter

TL;DR: The observed combined effect of a 3-compounds mixture of prometryn, N-phenyl-2-naphthylamine, and benzo[ghi]fluoranthene is indistinguishable from the effects of the original 10-compound mixture, demonstrating the need in site-specific assessment of complex contamination to account for the mode of action of contaminants.

TL;DR: In this study the combined effect of a multiple mixture composed of structurally dissimilar priority pollutants with mostly unknown modes of action has been investigated using an algal biotest.

TL;DR: The necessity of considering the toxicities of chemical mixtures in the environment will be demonstrated, the applicability of Independent Action and Concentration Addition as tools for the prediction and assessment of mixture toxicities will be discussed and an overview of the specific aims and approaches of the BEAM project to fill in the identified knowledge gaps is given.

TL;DR: A procedure for classifying chemicals in relation to their structural and toxicological similarities has been developed and the predictive capabilities of CA and IA models have been demonstrated for single species and, to some extent, for multispecies testing.

TL;DR: Drawbacks of the established approach using toxic unit summation are demonstrated, and the Index of Confirmation Quality, an easy-to-read representation that allows a quantitative measure of confirmation over a range of different effect levels, is introduced.