H
Helle Krogh Johansen
Researcher at University of Copenhagen
Publications - 267
Citations - 14711
Helle Krogh Johansen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Pseudomonas aeruginosa & Cystic fibrosis. The author has an hindex of 59, co-authored 239 publications receiving 12595 citations. Previous affiliations of Helle Krogh Johansen include Copenhagen University Hospital & Novo Nordisk Foundation.
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Journal ArticleDOI
The clinical impact of bacterial biofilms
Niels Høiby,Oana Ciofu,Helle Krogh Johansen,Zhijun Song,Claus Moser,Peter Østrup Jensen,Søren Molin,Michael Givskov,Tim Tolker-Nielsen,Thomas Bjarnsholt +9 more
TL;DR: Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body and they can be treated by chronic suppressive antibiotic therapy.
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Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
Anders Folkesson,Lars Jelsbak,Lei Yang,Lei Yang,Helle Krogh Johansen,Oana Ciofu,Niels Høiby,Niels Høiby,Søren Molin +8 more
TL;DR: This work discusses how P. aeruginosa evolves from a state of early, recurrent intermittent colonization of the airways of patients with CF to a chronic infection state, and how this process offers opportunities to study bacterial evolution in natural environments.
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Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis
TL;DR: The analysis of 36 P. aeruginosa lineages identified convergent molecular evolution in 52 genes that suggest a role in host adaptation for remodeling of regulatory networks and central metabolism, acquisition of antibiotic resistance and loss of extracellular virulence factors.
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Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB‐oprM genes
TL;DR: It is demonstrated that the subpopulation of metabolically active cells in Pseudomonas aeruginosa biofilms is able to adapt to colistin by inducing a specific adaptation mechanism mediated by the pmr operon, as well as an unspecific adaptation mechanismmediated by the mexAB‐oprM genes.
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Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth.
TL;DR: The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa, which occurs in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response.